CAS 80206-91-3

8-(p-Sulfophenyl)theophylline

Description:

8-(p-Sulfophenyl)theophylline is a synthetic derivative of theophylline, which is a methylxanthine compound known for its role as a bronchodilator and its use in treating respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). This compound features a sulfonic acid group, which enhances its solubility in water, making it suitable for various biological applications. The presence of the p-sulfophenyl group contributes to its unique pharmacological properties, potentially influencing its interaction with biological targets. Typically, compounds like 8-(p-Sulfophenyl)theophylline are studied for their effects on adenosine receptors and phosphodiesterase inhibition, which can lead to increased levels of cyclic AMP in cells. This compound may also exhibit antioxidant properties and has been investigated for its potential therapeutic effects beyond respiratory conditions. As with many chemical substances, its safety profile, including toxicity and side effects, would need to be evaluated in the context of its intended use.

Formula: C₁₃H₁₂N₄O₅S

InChI: InChI=1/C13H12N4O5S/c1-16-11-9(12(18)17(2)13(16)19)14-10(15-11)7-3-5-8(6-4-7)23(20,21)22/h3-6H,1-2H3,(H,14,15)(H,20,21,22)

InChI key: InChIKey=LXJSJIXZOAMHTG-UHFFFAOYSA-N

SMILES: O=C1C2=C(N=C(N2)C3=CC=C(S(=O)(=O)O)C=C3)N(C)C(=O)N1C

Synonyms:

• 1,3-Dimethyl-8-(p-sulfophenyl)xanthine
• 4-(1,3-dimethyl-2,6-dioxo-2,3,6,9-tetrahydro-1H-purin-8-yl)benzenesulfonic acid
• 4-(2,3,6,7-Tetrahydro-1,3-dimethyl-2,6-dioxo-1H-purin-8-yl)benzenesulfonic acid
• 8-(4-Sulfophenyl)theophylline
• 8-Pspt
• 8-Spt
• 8-Sulfophenyltheophylline
• 8-Sulphophenyltheophylline
• Benzenesulfonic acid, 4-(2,3,6,7-tetrahydro-1,3-dimethyl-2,6-dioxo-1H-purin-8-yl)-
• Psp-theophylline
• 8-(p-Sulfophenyl)theophylline
• 8-(p-Sulfophenyl)theophylline
• 4-(1,3-dimethyl-2,6-dioxo-7H-purin-8-yl)benzenesulfonic acid
• 8-p-(Sulpho Phenyl) Theophylline hydrate
• 8-p-ST
• 8-(p-sulfophenyl)theophylline hydrate
• NCGC00015000-01
• 8-(P-SULFOPHENYL)THEOPHYLLINE ADENOSINE ANTAGONIST
• adenosineantagonist
• 8-Sulfophenyltheophyl
• 4-[(1,3-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin)-8-yl]benzenesulfonic acid
• Lopac-A-013
• NCGC00093625-03
• 8-Pspt, 8-SPT
• EU-0100135
• 8-(4-Sulfophenyl)theophyline
• 4-(2,6-diketo-1,3-dimethyl-7H-purin-8-yl)benzenesulfonic acid

8(-p-Sulfophenyl)theophylline

Controlled Product

CAS: 80206-91-3

Applications 8(p-Sulfophenyl)theophylline is a polar adenosine receptor antagonist.
References Brackett, L., et al.: Biochem. Pharmacol., 47, 801 (1994); Jarvis, M., et al.: J. P harmacol. Exp. Ther., 251, 888 (1989); Daly, J., et al.: J. Med. Chem., 28, 487 (1985);

Formula: C₁₃H₁₂N₄O₅S

Color and Shape: White To Off-White

Molecular weight: 336.323

Ref: TR-S699283

8-(p-Sulfophenyl)theophylline

CAS: 80206-91-3

8-(p-Sulfophenyl)theophylline is a potent and selective A1 adenosine receptor agonist that has been shown to produce bronchoconstriction in vivo. This drug produces a significant increase in locomotor activity and has been used as a model of theophylline-induced bronchoconstriction. 8-(p-Sulfophenyl)theophylline binds to the A3 adenosine receptor, which is involved in regulating cardiac function and blood pressure. The drug also inhibits cyclase activity and has been shown to be effective against experimental models of myocardial infarction.

Formula: C₁₃H₁₂N₄O₅S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 336.32 g/mol

Ref: 3D-FS138816