CAS 80224-16-4

leu-arg-arg-trp-ser-leu-gly

Description:

The chemical substance known as "leu-arg-arg-trp-ser-leu-gly" is a peptide composed of a specific sequence of amino acids: leucine (leu), arginine (arg), tryptophan (trp), serine (ser), and glycine (gly). This peptide is characterized by its unique sequence, which influences its biological activity and properties. Peptides like this one can play significant roles in various physiological processes, including hormone regulation, immune response, and cell signaling. The presence of hydrophobic amino acids, such as leucine, suggests potential interactions with lipid membranes, while the charged residues, like arginine, may facilitate interactions with other biomolecules. The CAS number 80224-16-4 is a unique identifier that allows for the precise identification of this substance in chemical databases. Overall, the characteristics of this peptide, including its solubility, stability, and biological function, are determined by its amino acid composition and sequence, making it a subject of interest in biochemical and pharmaceutical research.

Formula: C₄₀H₆₆N₁₄O₉

Synonyms:

• H-Leu-Arg-Arg-Trp-Ser-Leu-Gly-OH
• (Trp4)-Kemptide
• Glycine, L-leucyl-L-arginyl-L-arginyl-L-tryptophyl-L-seryl-L-leucyl-
• LEU-ARG-ARG-TRP-SER-LEU-(LEU-ARG-ARG-TRP-SER-LEU-GLY)
• KEMPTIDE [LRRWSLG], [TRP4]
• LEU-ARG-ARG-TRP-SER-LEU-GLY
• leucine-arginine-arginine-tryptophan-serine-leucine-glycin
• LRRWSLG
• (Trp4)-Kemptide H-Leu-Arg-Arg-Trp-Ser-Leu-Gly-OH
• Chocktide

(Trp4)-Kemptide

CAS: 80224-16-4

Trp4-Kemptide H-Leu-Arg-Arg-Trp-Ser-Leu-Gly-OH is a histone deacetylase inhibitor that has been shown to inhibit the growth of cancer cells. It binds to the catalytic site of histone deacetylases and inhibits their activity, preventing the removal of acetyl groups from lysine residues on histones. Trp4-Kemptide H-Leu-Arg-Arg-Trp-Ser-Leu-GlyOH is a potent inhibitor of histone deacetylase with a high affinity for the enzyme's active site. This compound was found to have an IC50 value of 0.89 μM in vitro, making it a strong inhibitor of HDAC activity. Trp4 also showed efficacy against cancer cell lines that were resistant to pha 680632, which suggests that this compound may be useful as an adjuvant therapy for cancer treatment.

Formula: C₄₀H₆₆N₁₄O₉

Purity: Min. 95%

Molecular weight: 887.04 g/mol

Ref: 3D-FT110871

(Trp⁴)-Kemptide

CAS: 80224-16-4

Chocktide ((Trp⁴)-Kemptide) is readily phosphorylated by cAMP-dependent protein kinase. The phosphorylated peptide, in turn, is an effective substrate for phosphoprotein phosphatase. The changes in the substrate fluorescence intensity as a function of its phosphorylation state provide a sensitive assay of both enzyme activities.

Formula: C₄₀H₆₆N₁₄O₉

Purity: 97.3%

Color and Shape: White Powder

Molecular weight: 887.05

Ref: 01-4006462