CAS 80234-20-4

N-Didesmethyltamoxifen

Description:

N-Didesmethyltamoxifen is a chemical compound that is a derivative of tamoxifen, a well-known selective estrogen receptor modulator (SERM) primarily used in the treatment of breast cancer. This compound is characterized by its structural modifications that result in altered pharmacological properties compared to its parent compound. N-Didesmethyltamoxifen exhibits a similar mechanism of action, interacting with estrogen receptors, but may have different efficacy and side effect profiles. It is typically studied for its potential therapeutic applications and effects on estrogen signaling pathways. The compound is identified by its CAS number 80234-20-4, which is a unique numerical identifier used to provide a standardized reference for chemical substances. As with many pharmaceuticals, the safety, efficacy, and specific biological activities of N-Didesmethyltamoxifen are subjects of ongoing research, and its use would be guided by clinical findings and regulatory approvals.

Formula: C₂₄H₂₅NO

InChI: InChI=1S/C24H25NO/c1-2-23(19-9-5-3-6-10-19)24(20-11-7-4-8-12-20)21-13-15-22(16-14-21)26-18-17-25/h3-16H,2,17-18,25H2,1H3/b24-23-

InChI key: InChIKey=MCJKBWHDNUSJLW-VHXPQNKSSA-N

SMILES: C(=C(/CC)\C1=CC=CC=C1)(\C2=CC=C(OCCN)C=C2)/C3=CC=CC=C3

Synonyms:

• (Z)-1-[4-(2-Aminoethoxy)phenyl]-1,2-diphenylbut-1-ene
• 2-[4-(1,2-Diphenyl-but-1-enyl)-phenoxy]-ethylamine
• 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]ethanamine
• Desdimethyltamoxifen
• Di-N-demethyltamoxifen
• Didemethyltamoxifen
• Ethanamine, 2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-, (Z)-
• Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-
• Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-butenyl]phenoxy]-
• Ici 142268
• N,N-Didemethyltamoxifen
• N,N-Didesmethyltamoxifen
• N-Des(dimethyl)tamoxifen

Didesmethyl Tamoxifen

CAS: 80234-20-4

Formula: C₂₄H₂₅NO

Molecular weight: 343.47

Ref: 4Z-T-016

N,N-Didesmethyl tamoxifen

CAS: 80234-20-4

N,N-Didesmethyl tamoxifen is a metabolite of tamoxifen and belongs to the class of estrogen receptor modulators. It has been shown that this drug binds to liver cells and has a carcinogenic potential in animals. N,N-Didesmethyl tamoxifen is a substrate for cytochrome P450 2D6 (CYP2D6) and is converted to endoxifen. Endoxifen inhibits the growth of cancer cells by binding to estrogen receptors on the cell surface and preventing the natural ligand estradiol from binding with these receptors. The clinical response to tamoxifen treatment may be influenced by genetic polymorphisms in CYP2D6.

Formula: C₂₄H₂₅NO

Purity: Min. 95%

Molecular weight: 343.5 g/mol

Ref: 3D-FDA23420