Nafamostat (hydrochloride), with the CAS number 80251-32-7, is a synthetic serine protease inhibitor primarily used in medical applications, particularly in the treatment of pancreatitis and as an anticoagulant during certain surgical procedures. It exhibits a high affinity for various serine proteases, including trypsin and thrombin, which contributes to its therapeutic effects. Nafamostat is characterized by its ability to inhibit the activation of coagulation pathways, making it valuable in managing conditions that require anticoagulation. The compound is typically administered intravenously due to its rapid metabolism and short half-life. In terms of physical properties, Nafamostat hydrochloride is a white to off-white crystalline powder, soluble in water, which facilitates its use in clinical settings. Its mechanism of action involves the reversible binding to the active site of serine proteases, thereby preventing substrate access and subsequent enzymatic activity. Ongoing research continues to explore its potential applications in various medical fields, including antiviral therapies and organ transplantation.

NafaMostat (hydrochloride)

80251-32-7: Nafamostat (hydrochloride), with the CAS number 80251-32-7, is a synthetic serine protease inhibitor primarily used in medical applications, particularly in the treatment of pancreatitis and as an anticoagulant during certain surgical procedures. It exhibits a high affinity for various serine proteases, including trypsin and thrombin, which contributes to its therapeutic effects. Nafamostat is characterized by its ability to inhibit the activation of coagulation pathways, making it valuable in managing conditions that require anticoagulation. The compound is typically administered intravenously due to its rapid metabolism and short half-life. In terms of physical properties, Nafamostat hydrochloride is a white to off-white crystalline powder, soluble in water, which facilitates its use in clinical settings. Its mechanism of action involves the reversible binding to the active site of serine proteases, thereby preventing substrate access and subsequent enzymatic activity. Ongoing research continues to explore its potential applications in various medical fields, including antiviral therapies and organ transplantation.

<p>Nafamostat hydrochloride is a synthetic serine protease inhibitor and is an anticoagulant.</p>

CAS 80251-32-7

NafaMostat (hydrochloride)

Nafamostat hydrochloride

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