CAS 802918-57-6

Silybin

Description:

Silybin, also known as silibinin, is a flavonoid compound derived from the milk thistle plant (Silybum marianum). It is primarily recognized for its hepatoprotective properties, making it a popular supplement for liver health. Silybin exhibits antioxidant activity, which helps to neutralize free radicals and reduce oxidative stress in cells. The compound is known to interact with various cellular pathways, potentially influencing inflammation and cellular signaling. Silybin is often studied for its potential therapeutic effects in conditions such as liver cirrhosis, hepatitis, and even certain types of cancer. It is typically available in the form of silymarin, a complex of flavonolignans that includes silybin as its major active component. In terms of solubility, silybin is relatively poorly soluble in water but can be enhanced through various formulations. Its safety profile is generally favorable, although some individuals may experience gastrointestinal disturbances. Overall, silybin is a compound of significant interest in both traditional herbal medicine and modern pharmacological research.

Formula: C₂₅H₂₂O₁₀

Synonyms:

• 4H-1-Benzopyran-4-one, 2-[2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-
• Silybin A,B (Mixture)
• Silybin (Mixture of Diastereomers)

Silybin

CAS: 802918-57-6

Silybin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Formula: C₂₅H₂₂O₁₀

Purity: (HPLC) ≥95% (total of isomers)

Color and Shape: Powder

Molecular weight: 482.45

Ref: 11-1040

Silybin

CAS: 802918-57-6

Silybin is a flavonoid from Silybum that inhibits P-gp-assisted extracellular efflux, inhibits cytochrome P450 enzymes，anti-inflammatory， Hepatoprotective.

Formula: C₂₅H₂₂O₁₀

Purity: 98.12%

Color and Shape: Solid

Molecular weight: 482.44

Ref: TM-T75437

Silybin

CAS: 802918-57-6

Silybin

Purity: ≥98%

Molecular weight: 482.44g/mol

Ref: 54-BUP20903

Silybin

CAS: 802918-57-6

Silymarin (SIL), a standardized plant extract containing about 60% polyphenole silibinin, is used as a hepatoprotective agent, it retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats, it also may play a role in the therapy of (alcoholic) liver cirrhosis.[1,2]

Formula: C₂₅H₂₂O₁₀

Purity: 95%~99%

Color and Shape: White powder

Molecular weight: 482.441

Ref: BP-BP1305

Silybin (Mixture of Silybin A and B)

CAS: 802918-57-6

Formula: C₂₅H₂₂O₁₀

Color and Shape: Neat

Molecular weight: 482.44

Ref: 04-C16948000

Silybin-d3 (Mixture of Diastereomers)

CAS: 802918-57-6

Formula: C₂₅H₁₉O₁₀D₃

Molecular weight: 485.47

Ref: 4Z-S-396

Silybin (a + b mixture)

CAS: 802918-57-6

Oxygen-heterocyclic compound

Formula: C₂₅H₂₂O₁₀

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 482.44

Ref: 5G-89280

Silybin A,B (mixture)

CAS: 802918-57-6

Applications Hepatoprotectant. In nature, the flavonolignan Silybin occurs as a mixture of two diastereomers, Silybin A and Silybin B.
References Xu, P., et al.: Int. J. Biol. Macromol., 47, 654 (2010), Ravichandran, K., et al.: Clin. Canc. Res., 16, 4595 (2010), Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010),

Formula: C₂₅H₂₂O₁₀

Color and Shape: Light Yellow To Brown

Molecular weight: 482.44

Ref: TR-S465850

(2R,3R)-3,5,7-Trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-o ne

CAS: 802918-57-6

(2R,3R)-3,5,7-Trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-o ne is a natural compound that has been shown to have cytotoxic activity against murine hepatoma cells and human skin cancer cells. It also has antiinflammatory properties and inhibits acetylcholinesterase. This compound may be used as an adjuvant treatment for autoimmune diseases or in the preparation of primary cells for mitochondrial functions studies.

Formula: C₂₅H₂₂O₁₀

Purity: Min. 95%

Molecular weight: 482.4 g/mol

Ref: 3D-CHB91857