Complement C5a is a small peptide that plays a crucial role in the immune response, specifically in the complement system, which is part of the innate immune system. It is generated from the cleavage of complement component C5 by the enzyme C5 convertase. C5a is known for its potent pro-inflammatory properties, acting as a chemotactic factor that attracts immune cells, such as neutrophils and monocytes, to sites of infection or injury. This peptide is characterized by its ability to bind to specific receptors on immune cells, leading to various biological responses, including the release of inflammatory mediators. Additionally, C5a is involved in enhancing vascular permeability and promoting the activation of other immune pathways. Due to its significant role in inflammation and immune regulation, C5a has been implicated in various pathological conditions, including autoimmune diseases and sepsis. Its study is important for understanding immune responses and developing therapeutic strategies targeting complement-mediated diseases.

Complement C5a

80295-54-1: Complement C5a is a small peptide that plays a crucial role in the immune response, specifically in the complement system, which is part of the innate immune system. It is generated from the cleavage of complement component C5 by the enzyme C5 convertase. C5a is known for its potent pro-inflammatory properties, acting as a chemotactic factor that attracts immune cells, such as neutrophils and monocytes, to sites of infection or injury. This peptide is characterized by its ability to bind to specific receptors on immune cells, leading to various biological responses, including the release of inflammatory mediators. Additionally, C5a is involved in enhancing vascular permeability and promoting the activation of other immune pathways. Due to its significant role in inflammation and immune regulation, C5a has been implicated in various pathological conditions, including autoimmune diseases and sepsis. Its study is important for understanding immune responses and developing therapeutic strategies targeting complement-mediated diseases.

<p>c5A (His-tag) from mouse is a mitochondrial membrane potential inhibitor that binds to the c5A subunit of the cytosolic ATP synthase complex. This protein is a major component of the mitochondrial F1F0-ATP synthase and regulates cellular ATP production by catalyzing the synthesis of ATP from ADP and phosphate. The c5A subunit has been shown to have an inhibitory effect on pandemic influenza virus replication in vitro, with an IC50 value of 2.3 μM. The c5A subunit also has anti-inflammatory effects by inhibiting IL-10 gene transcription in renal cells.</p>

CAS 80295-54-1

Complement C5a

c5A (His-tag) from mouse

Ref: 3D-FDA29554