CAS 803712-67-6

Obatoclax

Description:

Obatoclax, with the CAS number 803712-67-6, is a small molecule that functions primarily as a Bcl-2 family inhibitor, targeting proteins involved in the regulation of apoptosis (programmed cell death). It is characterized by its ability to disrupt the interactions between pro-apoptotic and anti-apoptotic proteins, thereby promoting cell death in cancer cells. Obatoclax has shown potential in preclinical studies and clinical trials for various types of cancers, including hematological malignancies and solid tumors. The compound is typically administered in a clinical setting and has been investigated for its efficacy in combination with other therapeutic agents. Its mechanism of action involves the induction of apoptosis through the mitochondrial pathway, making it a subject of interest in cancer research. Additionally, Obatoclax's pharmacokinetics, including absorption, distribution, metabolism, and excretion, are crucial for understanding its therapeutic potential and optimizing its use in clinical applications. As with many investigational drugs, ongoing studies continue to evaluate its safety and effectiveness in diverse patient populations.

Formula: C₂₀H₁₉N₃O

InChI: InChI=1S/C20H19N3O/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17/h4-11,21-22H,1-3H3

InChI key: InChIKey=RFTSSZJZXOSICM-UHFFFAOYSA-N

SMILES: C(=C1N=C(C=C1OC)C2=CC=3C(N2)=CC=CC3)C4=C(C)C=C(C)N4

Synonyms:

• GX 15-070
• 1H-Indole, 2-[2-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-
• Obatoclax
• GX 015-070
• 2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole

1H-Indole,2-[2-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-

CAS: 803712-67-6

Formula: C₂₀H₁₉N₃O

Purity: 98%

Color and Shape: Solid

Molecular weight: 317.3844

Ref: IN-DA005B9O

Obatoclax

CAS: 803712-67-6

Obatoclax

Purity: ≥98%

Molecular weight: 317.38g/mol

Ref: 54-BUP13862

Obatoclax

CAS: 803712-67-6

Obatoclax is a small molecule drug that induces apoptosis by binding to the MCL-1 protein. It has been shown to induce apoptosis in human cancer cells, including t-cell lymphoma and leukemia, through a caspase-independent pathway. Obatoclax binds to the BCL-2 family proteins, inhibiting mitochondrial membrane potential and ATP synthesis. This leads to cell death through energy metabolism failure.

Formula: C₂₀H₁₉N₃O

Purity: Min. 95%

Molecular weight: 317.4 g/mol

Ref: 3D-DHB71267

Obatoclax

CAS: 803712-67-6

Obatoclax (GX15-070), a pan-BCL-2 inhibitor (Ki 220 nM) induces autophagy, degrades cyclin D1, and has anti-cancer/antiparasitic properties.

Formula: C₂₀H₁₉N₃O

Purity: 99.44%

Color and Shape: Solid

Molecular weight: 317.38

Ref: TM-T41278