CAS 804-63-7

Quinine sulfate

Description:

Quinine sulfate is an alkaloid derived from the bark of the cinchona tree, primarily known for its antimalarial properties. It is a white, crystalline powder that is slightly soluble in water and more soluble in alcohol. The compound has a bitter taste, which is a characteristic feature of quinine and its derivatives. Quinine sulfate is often used in the treatment of malaria, particularly in cases of severe infection, and it also has applications in treating nocturnal leg cramps. The chemical structure of quinine sulfate includes a complex bicyclic system, which contributes to its pharmacological effects. It acts by interfering with the parasite's ability to metabolize and utilize hemoglobin, ultimately leading to its death. Additionally, quinine sulfate has been used historically as a flavoring agent in tonic water, providing a distinctive bitterness. However, its use has declined due to potential side effects, including cinchonism, which can cause symptoms such as tinnitus and nausea. Overall, quinine sulfate remains an important compound in both medicinal and historical contexts.

Formula: C₂₀H₂₄N₂O₂H₂O₄S

InChI: InChI=1S/C20H24N2O2.H2O4S/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4)/t13-,14-,19-,20+;/m0./s1

InChI key: InChIKey=AKYHKWQPZHDOBW-DSXUQNDKSA-N

SMILES: S(=O)(=O)(O)O.[C@@H](O)(C=1C2=C(C=CC(OC)=C2)N=CC1)[C@]3([N@@]4C[C@H](C=C)[C@](C3)(CC4)[H])[H]

Synonyms:

• (8alpha,9R)-6'-methoxycinchonan-9-ol sulfate (1:1)
• (8alpha,9R)-6'-methoxycinchonan-9-ol sulfate (2:1)
• Aflukin
• Chinin
• Chinine
• Cinchonan-9-ol, 6′-methoxy-, (8α,9R)-, sulfate (2:1)
• Cinchonan-9-ol, 6′-methoxy-, (8α,9R)-, sulfate (2:1) (salt)
• Coco-Quinine
• NSC 5362
• Quinersol
• Quinine hemisulfate
• Quinine sulfate (2:1)
• Quinine sulfuric acid
• Quinine, sulfate (2:1) (salt)
• Quinoc

Quinine hemisulfate

CAS: 804-63-7

Quinidine: antiarrhythmic, orally active, inhibits cytochrome P450db, blocks K+ channels (IC50: 19.9μM), may aid in malaria research.

Formula: C₄₀H₅₀N₄O₈S

Purity: 98%

Color and Shape: Solid

Molecular weight: 746.92

Ref: TM-T21266

Quinine Sulfate

CAS: 804-63-7

Formula: C₂₀H₂₄N₂O₂H₂SO₄

Molecular weight: 324.4 : 98.1

Ref: ST-EA-CP-A67077