CAS 80418-24-2
:Notoginsenoside R1
Description:
Notoginsenoside R1 is a triterpenoid saponin primarily derived from the roots of Panax notoginseng, a plant known for its medicinal properties in traditional Chinese medicine. This compound is characterized by its complex structure, which includes a steroid-like backbone with multiple hydroxyl groups and a sugar moiety, contributing to its bioactivity. Notoginsenoside R1 exhibits various pharmacological effects, including anti-inflammatory, antioxidant, and neuroprotective properties. It has been studied for its potential in enhancing cognitive function and promoting cardiovascular health. The compound is typically soluble in organic solvents and exhibits low solubility in water, which can influence its bioavailability and therapeutic efficacy. Additionally, Notoginsenoside R1 is often investigated for its role in modulating signaling pathways related to cell survival and apoptosis, making it a subject of interest in pharmacological research. Overall, Notoginsenoside R1 represents a significant component of Panax notoginseng, contributing to its health benefits and therapeutic applications.
Formula:C47H80O18
InChI:InChI=1S/C47H80O18/c1-21(2)10-9-13-47(8,65-41-37(59)34(56)32(54)26(18-48)62-41)22-11-15-45(6)30(22)23(50)16-28-44(5)14-12-29(52)43(3,4)39(44)25(17-46(28,45)7)61-42-38(35(57)33(55)27(19-49)63-42)64-40-36(58)31(53)24(51)20-60-40/h10,22-42,48-59H,9,11-20H2,1-8H3/t22-,23+,24+,25-,26+,27+,28+,29-,30-,31-,32+,33+,34-,35-,36+,37+,38+,39-,40-,41-,42+,44+,45+,46+,47-/m0/s1
InChI key:InChIKey=LLPWNQMSUYAGQI-OOSPGMBYSA-N
SMILES:C[C@]12[C@@]3(C)[C@@]([C@@]([C@@](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)(CCC=C(C)C)C)(CC3)[H])([C@H](O)C[C@@]1([C@]5(C)[C@@]([C@@H](O[C@H]6[C@H](O[C@H]7[C@H](O)[C@@H](O)[C@H](O)CO7)[C@@H](O)[C@H](O)[C@@H](CO)O6)C2)(C(C)(C)[C@@H](O)CC5)[H])[H])[H]
Synonyms:- (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-beta-D-xylopyranosyl-beta-D-glucopyranoside
- (3β,6α,12β)-20-(β-<span class="text-smallcaps">D</smallcap>-Glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-<smallcap>D</smallcap>-xylopyranosyl-β-<smallcap>D</span>-glucopyranoside
- (6beta,8xi,9xi,12alpha,13xi,14beta)-17-[(1S)-1-(beta-D-glucopyranosyloxy)-1,5-dimethylhex-4-en-1-yl]-3,12-dihydroxy-4,4,10,14-tetramethylgonan-6-yl 2-O-beta-D-xylopyranosyl-beta-D-glucopyranoside
- Dammarane, β-<span class="text-smallcaps">D</span>-glucopyranoside deriv.
- Netoginsenoside
- Notoginsenoside R 1
- Notoginsenoside R1
- Notoginsenoside R<sub>1</sub>
- Sanchinoside R<sub>1</sub>
- Sanqi glucoside R1
- beta-D-Glucopyranoside, (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-beta-D-xylopyranosyl-
- β-<span class="text-smallcaps">D</smallcap>-Glucopyranoside, (3β,6α,12β)-20-(β-<smallcap>D</smallcap>-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-<smallcap>D</span>-xylopyranosyl-
- (3β,6α,12β)-20-(β-D-Glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-D-xylopyranosyl-β-D-glucopyranoside
- Sanchinoside R1
- β-D-Glucopyranoside, (3β,6α,12β)-20-(β-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-D-xylopyranosyl-
- See more synonyms
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Found 12 products.
Notoginsenoside R1
CAS:Formula:C47H80O18Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:933.14Notoginsenoside R1
CAS:Notoginsenoside R1 analytical standard provided with w/w absolute assay, to be used for quantitative titration.Formula:C47H80O18Purity:(HPLC) ≥98%Color and Shape:PowderMolecular weight:933.15b-D-Glucopyranoside,(3b,6a,12b)-20-(b-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-b-D-xylopyranosyl-
CAS:Formula:C47H80O18Purity:98%Color and Shape:SolidMolecular weight:933.1273Notoginsenoside R1
CAS:Notoginsenoside R1(NR1) is the main ingredient with cardiovascular activity in Panax notoginseng, which has some neuronal protective, antihypertensive,antioxidant, anti-inflammatory, antiapoptotic, and immune-stimulatory activities. NR1 can counteract endotoxin-induced activation of endothelial cells in vitro and endotoxin-induced lethality in mice in vivo. NR1 inhibits TNF-α-induced PAI-1 overexpression via extracellular signal-related kinases (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathways, it attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation.Formula:C47H80O18Purity:95%~99%Molecular weight:933.139Notoginsenoside R1
CAS:Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.Formula:C47H80O18Purity:99.69% - 99.91%Color and Shape:SolidMolecular weight:933.13Ref: TM-T2961
10mg42.00€25mg71.00€50mg92.00€100mg145.00€200mg219.00€500mg383.00€1mL*10mM (DMSO)43.00€Notoginsenoside r1
CAS:Natural glycosideFormula:C47H80O18Purity:≥ 90.0 % (HPLC)Color and Shape:PowderMolecular weight:933.14Notoginsenoside R1
CAS:Notoginsenoside R1 is a saponin compound, which is a key bioactive ingredient derived from the roots of Panax notoginseng, a well-known traditional medicinal plant. This product is renowned for its diverse pharmacological activities, particularly its anti-inflammatory and antioxidant effects. The mode of action of Notoginsenoside R1 involves modulating various signaling pathways, including the NF-κB and MAPK pathways, which are pivotal in regulating the body's inflammatory response. Additionally, it exhibits the ability to scavenge free radicals, contributing to its antioxidative properties.
Formula:C47H80O18Purity:Min. 95%Color and Shape:White PowderMolecular weight:933.15 g/molNotoginsenoside R1
CAS:Controlled ProductApplications Notoginsenoside R1 acts as an anti-inflammatory agent, inhibiting TNF-α induced PAI-1 production in aortic smooth muscle cells in humans.
References Zhang, H. et al.: Vasc. Pharmacol., 44, 224 (2006);Formula:C47H80O18Color and Shape:NeatMolecular weight:933.13
