CAS 80433-71-2

Calcium levofolinate

Description:

Calcium levofolinate, also known as levoleucovorin, is a pharmaceutical compound primarily used as a chemoprotective agent in cancer therapy. It is the calcium salt of levofolinic acid, an active form of folate that plays a crucial role in cellular metabolism and DNA synthesis. This compound is characterized by its ability to enhance the efficacy of certain chemotherapeutic agents, particularly in the treatment of colorectal cancer, by mitigating the toxic effects of drugs like methotrexate. Calcium levofolinate is typically administered intravenously or orally and is known for its relatively low toxicity profile compared to other folate derivatives. Its mechanism of action involves the stabilization of the binding of 5-fluorouracil to thymidylate synthase, thereby improving the therapeutic outcomes in patients. Additionally, it is important to note that calcium levofolinate is often used in combination with other medications to optimize treatment regimens. As with any pharmaceutical, proper dosing and administration are critical to achieving the desired therapeutic effects while minimizing potential side effects.

Formula: C₂₀H₂₁CaN₇O₇

InChI: InChI=1/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12-,13+;/m0./s1

InChI key: InChIKey=BZPWXVJDMRBCMD-QNTKWALQSA-N

SMILES: C(=O)N1C2=C(NC[C@@H]1CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)NC(N)=NC2=O.[Ca]

Synonyms:

• Calcium (6S)-folinate
• L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1), (S)-
• (S)-Leucovorin calcium salt (1:1)
• L-Glutamic acid, N-[4-[[[(6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-, calcium salt (1:1)
• L-Glutamic acid, N-[4-[[[(6S)-2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-, calcium salt (1:1)
• 5-Formyl-(6S)-tetrahydrofolate calcium salt
• levoleucovorin calcium
• Isovorin
• Levofolinatecalcium
• L-LEUCOVORIN CALCIUM
• N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid Calcium Salt
• calcium (2R)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]amino}pentanedioate
• Calcium levofolinate
• calcium n-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-l-glutamate
• calcium levoleucovorin
• Elvorine
• Calcium-6-(s)-folinate
• L-Folinic acid calcium salt
• CL 307782
• levofolinic acid, calcium salt
• N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid Calcium Salt

L-Glutamic acid,N-[4-[[[(6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-, calcium salt (1:1)

CAS: 80433-71-2

Formula: C₂₀H₂₃CaN₇O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 513.5173

Ref: IN-DA00IMLO

Levoleucovorin Calcium

CAS: 80433-71-2

Levoleucovorin Calcium

Purity: ≥98%

Molecular weight: 511.5g/mol

Ref: 54-BUP15872

Levoleucovorin Calcium

CAS: 80433-71-2

Levoleucovorin Calcium (CL307782), a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.

Formula: C₂₀H₂₁N₇O₇·Ca

Purity: 99.07% - ≥98%

Color and Shape: White Crystalline Powder

Molecular weight: 511.5

Ref: TM-T6431

Calcium Levofolinate

Controlled Product

CAS: 80433-71-2

Applications Calcium levofolinate is a pharmaceutical drug that is used in biological studies for the treatment of colorectal cancer.
References Yoshino, T., et al.: Anticancer Res., 32, 973 (2012);

Formula: C₂₀H₂₃CaN₇O₇

Color and Shape: Neat

Molecular weight: 513.13

Ref: TR-C145635

calcium (2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioate

CAS: 80433-71-2

Purity: ≥99%

Molecular weight: 511.508

Ref: 10-F979354

Calcium Levofolinate-13C5

Controlled Product

CAS: 68538-85-2, 80433-71-2

Formula: C₅C₁₅H₂₃N₇O₇·Ca

Color and Shape: Neat

Molecular weight: 518.481

Ref: TR-C145637