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CAS 80458-10-2

:

(7S)-7-[(4-Carboxy-1-oxobutyl)amino]-7-methoxy-3-[[[(E)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl]oxy]methyl]cepham-3-ene-4-carboxylic acid

Description:
The chemical substance with the name "(7S)-7-[(4-Carboxy-1-oxobutyl)amino]-7-methoxy-3-[[[(E)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl]oxy]methyl]cepham-3-ene-4-carboxylic acid" and CAS number 80458-10-2 is a cephalosporin antibiotic, which belongs to the class of beta-lactam antibiotics. This compound exhibits a complex structure characterized by a beta-lactam ring, which is essential for its antibacterial activity. The presence of various functional groups, including carboxylic acid and methoxy groups, contributes to its solubility and reactivity. The molecule's stereochemistry, indicated by the (7S) configuration, plays a crucial role in its biological activity and interaction with bacterial enzymes. This antibiotic is designed to target and inhibit bacterial cell wall synthesis, making it effective against a range of gram-positive and some gram-negative bacteria. Its unique side chains enhance its pharmacological properties, potentially improving its efficacy and spectrum of activity compared to other cephalosporins. Overall, this compound represents a significant advancement in antibiotic development.
Synonyms:
  • (6R,7S)-7α-[(4-Carboxy-1-oxobutyl)amino]-3-[[[(E)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl]oxy]methyl]-7-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (7S)-7-[(4-Carboxy-1-oxobutyl)amino]-7-methoxy-3-[[[(E)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl]oxy]methyl]cepham-3-ene-4-carboxylic acid
  • Oganomycin GB
  • Oganomycin C1B
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  • Oganomycin GB
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    Oganomycin GB

    CAS:
    Oganomycin GB is derived from the bacterium Streptomyces (Streptomyces str. oganonensis YG 19Z). When sodium para-hydroxycinnamate is added to the fermentation medium, Oganomycin A is produced. This compound is converted into its glutaric acid derivative, Oganomycin GA, via the action of D-amino acid oxidase. After the removal of sulfate ester through acidic hydrolysis, both A and GA yield Oganomycin B and Oganomycin GB. The effectiveness of Oganomycin GB is greater against Gram-negative bacteria compared to Gram-positive bacteria.
    Formula:C23H24N2O10S
    Color and Shape:Solid
    Molecular weight:520.51

    Ref: TM-TN10966

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