CAS 80474-14-2

Fluticasone propionate

Description:

Fluticasone propionate is a synthetic corticosteroid with anti-inflammatory properties, primarily used in the treatment of respiratory conditions such as asthma and allergic rhinitis. It is characterized by its high potency and selective action on glucocorticoid receptors, which helps to reduce inflammation and immune response in the airways. The substance is typically administered via inhalation, nasal spray, or topical formulations, allowing for localized effects with minimal systemic absorption. Fluticasone propionate is known for its favorable pharmacokinetic profile, including a relatively long half-life and extensive first-pass metabolism, which contributes to its efficacy and safety. The compound is generally well-tolerated, although potential side effects may include local irritation, headache, or, with long-term use, systemic effects such as adrenal suppression. Its chemical structure includes a fluorinated steroid backbone, which enhances its potency and stability. Overall, fluticasone propionate is a critical medication in managing chronic inflammatory conditions, providing significant relief for patients when used appropriately.

Formula: C₂₅H₃₁F₃O₅S

InChI: InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1

InChI key: InChIKey=WMWTYOKRWGGJOA-CENSZEJFSA-N

SMILES: O(C(CC)=O)[C@@]1(C(SCF)=O)[C@]2(C)[C@@](C[C@H]1C)([C@]3([C@](F)([C@@H](O)C2)[C@]4(C)C([C@@H](F)C3)=CC(=O)C=C4)[H])[H]

Synonyms:

• Atemur Mite
• Axotide
• Cci 18781
• Cutivate
• Cutivate cream
• Cyclesonide
• F 9428
• Flixonase
• Flixonase Nasal Spray
• Flixotide
• Flixotide Disk
• Flixotide Disks
• Flixotide Inhaler
• Flonase
• Flonase Aq
• Flovent
• Flovent Diskus
• Flovent Rotadisk
• Flunase
• Fluticasone 17-propionate
• Fluticasone propionate
• Fluticone
• Flutide
• Flutide N
• Flutivate
• Rotadisk
• Zoflut

Fluticasone Propionate

CAS: 80474-14-2

Applications Fluticasone Propionate is a derivative of Flumethasone, a glucocorticoid. Fluticasone Propionate has antiallergic, anti-asthmatic, and anti-inflammatory properties (1,2,3).
References (1) Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990) (2) Mitchison, H.C., et al.: Gut, 32, 260 (1991) (3) Phillipps, G.H., et al.: J. Med. Chem., 37, 3717 (1994)

Formula: C₂₅H₃₁F₃O₅S

Color and Shape: White

Molecular weight: 500.57

Ref: TR-F599500

Fluticasone propionate - Bio-X ™

CAS: 80474-14-2

As a synthetic trifluorinated glucocorticoid receptor agonist, Fluticasone exhibits anti-inflammatory properties. When binding to and activating glucocorticoid receptors, Fluticasone initiates the activation of lipocortin which inhibits cytosolic phospholipase A2. Consequently, the cascade of inflammatory mediator synthesis reactions are inactivated and the production of inflammatory cells namely mast cells, dendritic cells, macrophages and eosinophils and the cytokines that they produce are greatly reduced.It is this anti-inflammatory role which has enabled Fluticasone to successfully treat conditions such as asthma, emphysema, allergic rhinitis and atopic dermatitis. It has also been seen to increase anti-inflammatory effects of annexoin-1 and mitogen-activated kinase phosphatase-1; reduce mucus gland secretions and increase the number of beta-2 receptors on smooth muscles of the airways.
Fluticasone is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₅H₃₁F₃O₅S

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 500.57 g/mol

Ref: 3D-BF161262

Fluticasone propionate - micronised pharma grade

CAS: 80474-14-2

Glucocorticoid receptor agonist; anti-inflammatory

Formula: C₂₅H₃₁F₃O₅S

Purity: (Hplc) 96.0 To 102.0%

Color and Shape: White Powder

Molecular weight: 500.57 g/mol

Ref: 3D-BF160362

Fluticasone propionate

CAS: 80474-14-2

Glucocorticoid receptor agonist; anti-inflammatory

Formula: C₂₅H₃₁F₃O₅S

Purity: Min. 97 Area-%

Color and Shape: White Powder

Molecular weight: 500.57 g/mol

Ref: 3D-FF23515