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CAS 80474-24-4

:

Fluticasone acetate

Description:
Fluticasone acetate is a synthetic corticosteroid with anti-inflammatory properties, primarily used in the treatment of respiratory conditions such as asthma and allergic rhinitis. It is characterized by its high potency and low systemic bioavailability, which minimizes potential side effects when administered via inhalation or nasal spray. The compound is a white to off-white powder, soluble in organic solvents like ethanol and acetone, but poorly soluble in water. Its molecular structure features a fluorinated steroid backbone, which contributes to its effectiveness in reducing inflammation by inhibiting the release of inflammatory mediators. Fluticasone acetate acts by binding to glucocorticoid receptors, leading to the modulation of gene expression involved in the inflammatory response. Due to its favorable pharmacokinetic profile, it is often preferred in clinical settings for managing chronic inflammatory conditions. However, long-term use may require monitoring for potential side effects, including local irritation or systemic effects, particularly in high doses.
Formula:C24H29F3O5S
InChI:InChI=1S/C24H29F3O5S/c1-12-7-15-16-9-18(26)17-8-14(29)5-6-21(17,3)23(16,27)19(30)10-22(15,4)24(12,32-13(2)28)20(31)33-11-25/h5-6,8,12,15-16,18-19,30H,7,9-11H2,1-4H3/t12-,15+,16+,18+,19+,21+,22+,23+,24+/m1/s1
InChI key:InChIKey=ODNKIHMUIGPTII-OSNGSNEUSA-N
SMILES:C[C@@]12[C@](C(SCF)=O)(OC(C)=O)[C@H](C)C[C@]1([C@]3([C@](F)([C@@H](O)C2)[C@]4(C)C([C@@H](F)C3)=CC(=O)C=C4)[H])[H]
Synonyms:
  • Androsta-1,4-diene-17-carbothioic acid, 17-(acetyloxy)-6,9-difluoro-11-hydroxy-16-methyl-3-oxo-, S-(fluoromethyl) ester, (6α,11β,16α,17α)-
  • Fluticasone acetate
  • Unii-1Bia3Zkx8V
  • [(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate
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