CAS 8052-16-2
:Actinomycin C
Description:
Actinomycin C, with the CAS number 8052-16-2, is a polypeptide antibiotic that is derived from the bacterium Streptomyces parvulus. It is known for its potent antitumor properties and is primarily used in cancer therapy. The compound exhibits a complex structure characterized by a cyclic peptide backbone and a phenoxazone chromophore, which contributes to its ability to intercalate into DNA. This intercalation inhibits RNA synthesis by preventing the transcription process, making it effective against rapidly dividing cancer cells. Actinomycin C is typically administered intravenously and has a range of side effects, including myelosuppression and gastrointestinal disturbances. Its solubility is generally low in water, but it is soluble in organic solvents, which is a consideration for its formulation in therapeutic applications. Due to its mechanism of action and biological activity, Actinomycin C is classified as a member of the actinomycin family, which has been pivotal in the development of chemotherapeutic agents.
Formula:Unspecified
InChI:InChI=1/C63H88N12O16/c1-17-31(8)44-61(86)75-25-19-21-38(75)59(84)71(14)27-40(77)73(16)50(30(6)7)63(88)90-35(12)46(57(82)67-44)69-55(80)41-42(64)51(78)33(10)53-48(41)65-47-36(23-22-32(9)52(47)91-53)54(79)68-45-34(11)89-62(87)49(29(4)5)72(15)39(76)26-70(13)58(83)37-20-18-24-74(37)60(85)43(28(2)3)66-56(45)81/h22-23,28-31,34-35,37-38,43-46,49-50H,17-21,24-27,64H2,1-16H3,(H,66,81)(H,67,82)(H,68,79)(H,69,80)/t31-,34+,35+,37-,38-,43-,44-,45-,46-,49-,50-/m0/s1
Synonyms:- 1H-Pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecine, cyclic peptide deriv.
- 3H-Phenoxazine, actinomycin C deriv.
- Cactinomycin
- Hbf 386
- NSC 18268
- NSC 87222
- Sanamycin
- Actinomycin C
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