CAS 806-29-1

(6α,11β)-6,9-Difluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione

Description:

The chemical substance "(6α,11β)-6,9-Difluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione," commonly known as dexamethasone, is a synthetic glucocorticoid with anti-inflammatory and immunosuppressant properties. It is characterized by its steroidal structure, which includes a cyclopentanoperhydrophenanthrene core, and specific functional groups that contribute to its biological activity. The presence of fluorine atoms enhances its potency and metabolic stability. Dexamethasone is typically administered in various forms, including oral tablets, injections, and topical formulations, and is used to treat a range of conditions such as allergies, autoimmune disorders, and certain cancers. Its mechanism of action involves binding to glucocorticoid receptors, leading to the modulation of gene expression and subsequent anti-inflammatory effects. The substance is also known for its side effects, which can include weight gain, increased blood sugar levels, and potential suppression of the adrenal gland function with prolonged use. Overall, dexamethasone is a crucial therapeutic agent in modern medicine, particularly in managing inflammatory and autoimmune conditions.

Formula: C₂₁H₂₆F₂O₅

InChI: InChI=1S/C21H26F2O5/c1-18-5-3-11(25)7-14(18)15(22)8-13-12-4-6-20(28,17(27)10-24)19(12,2)9-16(26)21(13,18)23/h3,5,7,12-13,15-16,24,26,28H,4,6,8-10H2,1-2H3/t12-,13-,15-,16-,18-,19-,20-,21-/m0/s1

InChI key: InChIKey=ABUISBDTYAZRHY-RBKZJGKHSA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)CC3)[H])(C[C@H](F)C=4[C@]2(C)C=CC(=O)C4)[H]

Synonyms:

• (6alpha,11beta)-6,9-Difluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione
• (6α,11β)-6,9-Difluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione
• 6,9-Difluoro-11,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione
• 6-Α-Fluoro-Isoflupredone
• 6α,9-Difluoroprednisolone
• 6α,9α-Difluoroprednisolone
• NSC 77021
• Pregna-1,4-Diene-3,20-Dione, 6,9-Difluoro-11,17,21-Trihydroxy-, (6Alpha,11Beta)-
• Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-, (6α,11β)-
• Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,17,21-trihydroxy-

6-α-Fluoro-isoflupredone

CAS: 806-29-1

Formula: C₂₁H₂₆F₂O₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 396.4249

Ref: IN-DA00G2BC

Difluprednate Impurity 18

CAS: 806-29-1

Formula: C₂₁H₂₆F₂O₅

Molecular weight: 396.43

Ref: 4Z-D-125023

6-alpha-Fluoro-isoflupredone

Controlled Product

CAS: 806-29-1

6-alpha-Fluoro-isoflupredone is a fine chemical that belongs to the class of versatile building blocks. It is a complex compound that has the CAS No. 806-29-1. This product can be used for research purposes, as well as in the production of other chemicals and pharmaceuticals. 6-alpha-Fluoro-isoflupredone is also a useful building block for complex compounds, and it can be used as a reagent or speciality chemical for various reactions. It is also a useful intermediate for reaction components or scaffolds in organic synthesis.

Formula: C₂₁H₂₆F₂O₅

Purity: Min. 96.0 Area-%

Molecular weight: 396.43 g/mol

Ref: 3D-Q-101390

6a,​9a-​Difluoroprednisolone

Controlled Product

CAS: 806-29-1

Applications 6α,9α-Difluoroprednisolone has shown to increase metastases and increase glucocorticoid activity in C57/BL6 mice.
References Albert, D., Zeidman, I.: Cancer Res., 22, 1297 (1962)

Formula: C₂₁H₂₆F₂O₅

Color and Shape: White To Light Beige

Molecular weight: 396.42

Ref: TR-D446290

6α,​9α-​Difluoroprednisolone

CAS: 806-29-1

Formula: C₂₁H₂₆F₂O₅

Molecular weight: 396.43

Ref: ST-EA-CP-P20014