CAS 80621-81-4

Rifaximin

Description:

Rifaximin is a broad-spectrum antibiotic belonging to the rifamycin class, primarily used to treat gastrointestinal infections, particularly those caused by non-invasive strains of Escherichia coli. Its chemical formula is C43H54N4O11S, and it has a molecular weight of approximately 785.98 g/mol. Rifaximin is characterized by its unique mechanism of action, which involves inhibiting bacterial RNA synthesis by binding to the beta-subunit of bacterial RNA polymerase. This action effectively disrupts protein synthesis in susceptible bacteria. One of the notable features of rifaximin is its poor systemic absorption, which allows it to act locally within the gastrointestinal tract while minimizing systemic side effects. It is often prescribed for conditions such as traveler's diarrhea and irritable bowel syndrome with diarrhea. Additionally, rifaximin has a favorable safety profile, with a low incidence of adverse effects, making it a preferred option for treating certain gastrointestinal disorders. Its stability and effectiveness against a range of Gram-positive and Gram-negative bacteria further enhance its therapeutic utility.

Formula: C₄₃H₅₁N₃O₁₁

InChI: InChI=1S/C43H51N3O11/c1-19-14-16-46-28(18-19)44-32-29-30-37(50)25(7)40-31(29)41(52)43(9,57-40)55-17-15-27(54-10)22(4)39(56-26(8)47)24(6)36(49)23(5)35(48)20(2)12-11-13-21(3)42(53)45-33(34(32)46)38(30)51/h11-18,20,22-24,27,35-36,39,48-51H,1-10H3,(H,45,53)/b12-11+,17-15+,21-13-/t20-,22+,23+,24+,27-,35-,36+,39+,43-/m0/s1

InChI key: InChIKey=NZCRJKRKKOLAOJ-XRCRFVBUSA-N

SMILES: O=C1C=2C=3C4=C(N5C(=N4)C=C(C)C=C5)C6=C(O)C3C(O)=C(C)C2O[C@]1(C)O/C=C/[C@H](OC)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(\C)/C(=O)N6

Synonyms:

• (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione
• (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,6,21,23,25-Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione,25-acetate
• 2,7-(Epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione, 25-(acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-, [2S-(2R*,16Z,18E,20R*,21R*,22S*,23S*,24S*,25R*,26S*,27R*,28E)]-
• L 105
• L 105 (ansamacrolide antibiotic)
• L 105Sv
• Normix
• Refaximin
• Rifamycin L 105
• Rifamycin L 105SV
• Rifaximin
• Xifaxan
• Xifaxanta

RIFAXIMIN FOR SYSTEM SUITABILITY CRS

CAS: 80621-81-4

RIFAXIMIN FOR SYSTEM SUITABILITY CRS

Formula: C₄₃H₅₁N₃O₁₁

Molecular weight: 785.8785

Ref: 41-Y0001075

RIFAXIMIN CRS

CAS: 80621-81-4

RIFAXIMIN CRS

Formula: C₄₃H₅₁N₃O₁₁

Color and Shape: Crystalline Powder. Red. Orange. Powder.

Molecular weight: 785.8785

Ref: 41-Y0001074

2,7-(Epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione,25-(acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-,(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-

CAS: 80621-81-4

Formula: C₄₃H₅₁N₃O₁₁

Purity: 97%

Color and Shape: Solid

Molecular weight: 785.8785

Ref: IN-DA00ILMS

Rifaximin

CAS: 80621-81-4

Rifaximin: an oral semi-synthetic antibiotic from rifamycin SV; targets bacterial RNA polymerase to halt growth.

Formula: C₄₃H₅₁N₃O₁₁

Purity: 99.18% - 99.40%

Color and Shape: Red-Orange Crystalline Powder

Molecular weight: 785.88

Ref: TM-T1154

Rifaximin

CAS: 80621-81-4

Rifaximin

Purity: ≥95%

Molecular weight: 785.88g/mol

Ref: 54-BUP17872

Rifaximin, Ph. Eur. grade

CAS: 80621-81-4

Formula: C₄₃H₅₁N₃O₁₁

Purity: ≤ 0.1%

Color and Shape: Red-orange crystalline powder

Molecular weight: 785.88

Ref: 7W-GA5441

Rifaximin

CAS: 80621-81-4

Formula: C₄₃H₅₁N₃O₁₁

Purity: 98.0 - 102.0 % (dried basis)

Color and Shape: Red-orange powder

Molecular weight: 785.88

Ref: 7W-GA5161

Rifaximin

CAS: 80621-81-4

Formula: C₄₃H₅₁N₃O₁₁

Color and Shape: Orange Solid

Molecular weight: 785.89

Ref: 4Z-R-352

Rifaximin

CAS: 80621-81-4

Rifaximin

Purity: 98%

Molecular weight: 785.88g/mol

Ref: 54-OR1030252

Rifaximin

Controlled Product

CAS: 80621-81-4

Formula: C₄₃H₅₁N₃O₁₁

Color and Shape: Neat

Molecular weight: 785.88

Ref: 04-C16814700

Rifaximin

CAS: 80621-81-4

Formula: C₄₃H₅₁N₃O₁₁

Purity: >97.0%(HPLC)(N)

Color and Shape: Orange to Brown powder to crystal

Molecular weight: 785.89

Ref: 3B-R0101

Rifaximin 1000 µg/mL in Acetonitrile

Controlled Product

CAS: 80621-81-4

Formula: C₄₃H₅₁N₃O₁₁

Color and Shape: Single Solution

Molecular weight: 785.88

Ref: 04-A16814700AL-1000

Rifaximin

CAS: 80621-81-4

Stability Hygroscopic
Applications Non-absorbable semisynthetic Rifamycin antibiotic.
References Brufani, M., et al.: J. Antibiot., 37, 1611 (1984), Gillis, J.C., et al.: Drugs, 49, 467 (1995), Huang, D.B., et al.: J. Infection, 50, 97 (2005),

Formula: C₄₃H₅₁N₃O₁₁

Color and Shape: Red

Molecular weight: 785.88

Ref: TR-R509500

Rifaximin

CAS: 80621-81-4

Rifaximin is a rifamycin antibiotic with action on bacterial RNA polymerase to inhibit transcription and is used for treating travelers' diarrhea, irritable bowel syndrome, and hepatic encephalopathy.

Formula: C₄₃H₅₁N₃O₁₁

Purity: Min. 98 Area-%

Color and Shape: Red Powder

Molecular weight: 785.88 g/mol

Ref: 3D-AR27732

Rifaximin (RFX) extrapure, 98%

CAS: 80621-81-4

Formula: C₄₃H₅₁N₃O₁₁

Purity: min. 98%

Color and Shape: Orange to red brown, Powder, Clear, Red to brown

Molecular weight: 785.88

Ref: SR-81319