CAS 8064-90-2

Sulfamethoxazole-trimethoprim mixt.

Description:

Sulfamethoxazole-trimethoprim mixt, commonly known as co-trimoxazole, is a combination antibiotic that consists of sulfamethoxazole, a sulfonamide, and trimethoprim, a dihydrofolate reductase inhibitor. This synergistic combination enhances the antibacterial efficacy against a broad spectrum of Gram-positive and Gram-negative bacteria. The mechanism of action involves the inhibition of bacterial folate synthesis, which is essential for nucleic acid production. The substance is typically administered in a fixed-dose formulation, making it effective in treating various infections, including urinary tract infections, respiratory infections, and certain gastrointestinal infections. It is generally well-absorbed and has a relatively long half-life, allowing for convenient dosing schedules. However, potential side effects may include allergic reactions, gastrointestinal disturbances, and hematological issues. Due to the risk of resistance development, its use is often guided by susceptibility testing. As with any antibiotic, it is crucial to use sulfamethoxazole-trimethoprim responsibly to minimize the emergence of resistant bacterial strains.

Formula: C₁₄H₁₈N₄O₃·C₁₀H₁₁N₃O₃S

InChI: InChI=1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)

InChI key: InChIKey=WZRJTRPJURQBRM-UHFFFAOYSA-N

SMILES: C(C1=CC(OC)=C(OC)C(OC)=C1)C=2C(N)=NC(N)=NC2.S(NC=1C=C(C)ON1)(=O)(=O)C2=CC=C(N)C=C2

Synonyms:

• 4-Amino-N-(5-methylisoxazol-3-yl)benzolsulfonamid--5-(3,4,5-trimethoxybenzyl)pyrimidin-2,4-diamin(1:1)
• Abacin
• Abactrim
• Acuco
• Alfatrim
• Andoprim
• Anitrim
• Antrimox
• Aop-Sulfatrim
• Apo-Sulfatrim
• BS
• Bacdan
• Bacidal
• Bacin
• Bacticel
• Bactifor
• Bactoprim
• Bactramin
• Bactrim
• Bactrimel
• Bactropin
• Baktar
• Bencole
• Bethaprim
• Biosulten
• Biseptol
• Brifeseptol
• Briscotrim
• Bronquimucil
• Centrim
• Chemitrim
• Chemotrim
• Ciplin
• Co-Trimoxazole
• Co-Trimoxizole
• Co-trimox
• Colizole
• Comox
• Conprim
• Cotrim
• Cotrim-Diolan
• Cotrimel
• Cotrimoxazol
• Deprim
• Diseptyl
• Drylin
• Duon
• Duratrimet
• Ectaprim
• Entrim
• Esbesul
• Espectrin
• Euctrim
• Eusaprim
• Exbesul
• Fectrim
• Fermagex
• Fortrim
• Futin
• Gantaprim
• Gantrim
• Hulin
• Ikaprim
• Imexim
• Intertrim
• Isotrim
• Kepinol
• Lagatrim
• Laratrim
• Lastrim
• Lescot
• Linaris
• Medixin
• Microtrim
• Nopil
• Novotrimel
• Omsat
• Omstat
• Oraprim
• Oriprim
• Oxaprim
• Pantoprim
• Purbal
• Resprim
• Roubal
• SXT
• Salvatrim
• Septazole
• Septra
• Septran
• Septrim
• Septrin
• Setprin
• Sigaprim
• Smx-Tmp
• Smz-Tmp
• Stopan
• Sugaprim
• Sulfacet
• Sulfamar
• Sulfamethoprim
• Sulfaprim
• Sulfatrim
• Sulfatrimethoprim
• Sulfazotrim
• Sulfazotrin
• Sulfinam
• Sulfotrim
• Sulfotrimin
• Sulfoxaprim
• Sulmeprim
• Sulphametrim
• Sulprim
• Sulthrim
• Sultrex
• Sumetrolim
• Supracombin
• Suprim
• Suprin
• Sutrim
• TMS
• Teleprim
• Thiocuran
• Tmp-Smx
• Tmp-Smz
• Trasepton
• Trigonyl
• Trim
• Trim-Sulfa
• Trimel
• Trimesulf
• Trimeth/sulfa
• Trimethazol
• Trimethoprimsulfa
• Trimetox
• Trimezol
• Trimezole
• Trimosulfa
• Trissulfin
• Trisul
• Trisulcom
• Trisulfam
• Trisural
• Trizole
• Ulfaprim
• Urobactrim
• Uroplus
• Xeroprim
• benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-, compd. with 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine (1:1)
• Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-, mixt. with 5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine
• Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-, mixt. with 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine
• 4-amino-N-(5-méthylisoxazol-3-yl)benzènesulfonamide - 5-(3,4,5-triméthoxybenzyl)pyrimidine-2,4-diamine (1:1)
• 4-Amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide - 5-(3,4,5-trimethoxybenzyl)-2,4-pyrimidinediamine (1:1)
• 4-Amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide - 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine (1:1)
• T6N CNJ BZ DZ E1R CO1 DO1 EO1 & T5NOJ C1 EMSWR DZ
• 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide - 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine (1:1)
• 2,4-Pyrimidinediamine, 5-[(3,4,5-trimethoxyphenyl)methyl]-, mixt. contg.

SMZ/TMP

CAS: 8064-90-2

Formula: C₂₄H₂₉N₇O₆S

Purity: 99.79%

Color and Shape: Solid

Molecular weight: 543.5954

Ref: IN-DA00GJ52

Trimosulfa

CAS: 8064-90-2

Trimosulfa

Purity: ≥98%

Molecular weight: 543.6g/mol

Ref: 54-BUP22147

Cotrimoxazole

CAS: 8064-90-2

Formula: C₁₄H₁₈N₄O₃·C₁₀H₁₁N₃O₃S

Molecular weight: 290.32 253.28

Ref: 4Z-C-215001

Cotrimoxazole

CAS: 8064-90-2

Applications Cotrimoxazole is an antibiotic. Pseudomonas aeruginosa has a drug resistant rate of 66% in the years 2010-2013.
References Sun, D., et. al.: Zhonghua Yiyuanganranxue Zazhi, 24, 345 (2014)

Formula: C₂₄H₂₉N₇O₆S

Color and Shape: Neat

Molecular weight: 543.6

Ref: TR-C725300

Cotrimoxazole (CTX), 95%

CAS: 8064-90-2

Formula: C₁₄H₁₈N₄O₃·C₁₀H₁₆N₃O₃S

Purity: min. 95%

Color and Shape: White to pale yellow, Crystalline powder

Molecular weight: 543.60

Ref: SR-10408

Trimosulfa

CAS: 8064-90-2

Trimosulfa is a combination of trimethoprim and sulfamethoxazole, an antibiotic combination. Sulfamethoxazole inhibits dihydropteroate synthase, while trimethoprim inhibits dihydrofolate reductase (dihydrofolate reductase), making it effective for mild to moderate bacterial infections against many Gram-negative and Gram-positive bacteria.

Formula: C₂₄H₂₉N₇O₆S

Purity: 99.93%

Color and Shape: Solid

Molecular weight: 543.6

Ref: TM-T24899

Cotrimoxazole-13C-d3

Controlled Product

CAS: 8064-90-2

Formula: CC₁₃H₁₅D₃N₄O₃·C₁₀H₁₁N₃O₃S

Color and Shape: Neat

Molecular weight: 294.33 + (253.28)

Ref: TR-C725304