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CAS 8067-24-1

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Dihydroergotoxine mesylate

Description:
Dihydroergotoxine mesylate is a semi-synthetic derivative of ergot alkaloids, primarily used for its pharmacological effects on the central nervous system and vascular system. It is characterized by its ability to improve cerebral blood flow and enhance cognitive function, making it relevant in the treatment of conditions such as dementia and other cognitive impairments. The compound exhibits a complex structure, featuring multiple chiral centers, which contributes to its biological activity. Dihydroergotoxine mesylate acts as a vasodilator and has been noted for its potential to modulate neurotransmitter release, particularly dopamine and serotonin. It is typically administered in a mesylate salt form, which enhances its solubility and stability. The substance is generally well-tolerated, but like many pharmacological agents, it may have side effects, including gastrointestinal disturbances or cardiovascular effects. As with any medication, its use should be guided by a healthcare professional, considering the patient's overall health and any potential drug interactions.
Formula:C20H29N3O5S
InChI:InChI=1/C33H45N5O5/c1-7-31(4,5)27-29(40)37-13-9-12-25(37)33(42)38(27)30(41)32(43-33,18(2)3)35-28(39)20-14-22-21-10-8-11-23-26(21)19(16-34-23)15-24(22)36(6)17-20/h8,10-11,16,18,20,22,24-25,27,34,42H,7,9,12-15,17H2,1-6H3,(H,35,39)
SMILES:CCC(C)(C)C1C(=O)N2CCCC2C2(N1C(=O)C(C(C)C)(N=C(C1CC3c4cccc5c4c(CC3N(C)C1)c[nH]5)O)O2)O
Synonyms:
  • (5'Alpha,10Alpha)-12'-Hydroxy-3',6',18-Trioxo-2',5'-Di(Propan-2-Yl)-9,10-Dihydroergotaman Methanesulfonate (1:1)
  • 12'-Hydroxy-5'-(2-Methylbutan-2-Yl)-3',6',18-Trioxo-2'-(Propan-2-Yl)-9,10-Dihydroergotaman
  • 8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine, ergotoxine deriv.
  • Alkergot
  • Cck 179
  • Circanol
  • Co-dercrine mesylate
  • Co-dergocrine mesylate
  • Codergine mesylate
  • Codergocrine methanesulfonate
  • See more synonyms
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