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CAS 8068-28-8

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Colistimethate

Description:
Colistimethate, also known as colistin methanesulfonate, is a polymyxin antibiotic primarily used to treat infections caused by multidrug-resistant Gram-negative bacteria. It is a prodrug that is converted in the body to colistin, the active form, which disrupts bacterial cell membranes, leading to cell death. Colistimethate is typically administered intravenously or via inhalation, particularly in cases of pneumonia or bloodstream infections. Its spectrum of activity includes pathogens such as Pseudomonas aeruginosa and Acinetobacter baumannii. However, its use is often limited by potential nephrotoxicity and neurotoxicity, necessitating careful monitoring of renal function during treatment. Colistimethate is classified as a last-resort antibiotic, reserved for severe infections where other treatments have failed. Due to the rise of antibiotic resistance, colistin has regained prominence in clinical settings, although its use is accompanied by concerns regarding the development of resistance. Overall, colistimethate is a critical tool in the fight against resistant bacterial infections, but its administration requires caution and expertise.
Formula:Unspecified
InChI:InChI=1/C53H100N16O13.5CH4O3S.5Na/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;5*1-5(2,3)4;;;;;/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);5*1H3,(H,2,3,4);;;;;/q;;;;;;5*+1/p-5/t30?,31-,32-,33+,34-,35+,36+,37+,38+,39+,40-,42?,43+;;;;;;;;;;/m1........../s1
SMILES:CCC(C)CCCCC(=NC(CCN)C(=NC(C(C)O)C(=NC(CCN)C(=NC1CCN=C(C(C(C)O)N=C(C(CCN)N=C(C(CCN)N=C(C(CC(C)C)N=C(C(CC(C)C)N=C(C(CCN)N=C1O)O)O)O)O)O)O)O)O)O)O.CS(=O)(=O)O.CS(=O)(=O)O.CS(=O)(=O)O.CS(=O)(=O)O.CS(=O)(=O)O.[Na].[Na].[Na].[Na].[Na]
Synonyms:
  • Colimycin M
  • Colimycin sodium methanesulfonate
  • Colistate
  • Colistimethate
  • Colistimethate sodique
  • Colistimethate sodium
  • Colistimethatnatrium
  • Colistin sodium methanesulfonate
  • Colistin sulfomethate
  • Colistin sulfomethate sodium
  • See more synonyms
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Found 14 products.