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CAS 808118-40-3

:

FG 4592

Description:
FG 4592, also known by its chemical name roxadustat, is a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH). It is primarily developed for the treatment of anemia associated with chronic kidney disease (CKD) and is notable for its ability to stimulate erythropoiesis by mimicking the physiological response to hypoxia. FG 4592 works by stabilizing HIF, leading to increased production of erythropoietin and other erythropoiesis-related factors. The compound is characterized by its oral bioavailability and a favorable pharmacokinetic profile, which allows for once-daily dosing. Its mechanism of action is distinct from traditional erythropoiesis-stimulating agents, making it a novel therapeutic option. Clinical studies have demonstrated its efficacy in increasing hemoglobin levels in patients with anemia due to CKD, with a safety profile that has been generally well-tolerated. As research continues, FG 4592 represents a significant advancement in the management of anemia in patients with renal impairment.
Formula:C19H16N2O5
InChI:InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)
InChI key:InChIKey=YOZBGTLTNGAVFU-UHFFFAOYSA-N
SMILES:CC=1C2=C(C(O)=C(C(NCC(O)=O)=O)N1)C=CC(OC3=CC=CC=C3)=C2
Synonyms:
  • (4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)glycine
  • Asp 1517
  • Glycine, N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-
  • N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine
  • Roxadustat
  • [(4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]glycine
  • [[(4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]amino]acetic acid
  • FG 4592
  • Roxadustat intermediates
  • 2-(4-HYDROXY-1-METHYL-7-PHENOXYISOQUINOLINE-3-CARBOXAMIDO)ACETIC ACID(Roxadustat)
  • See more synonyms
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