CAS 808118-40-3

FG 4592

Description:

FG 4592, also known by its chemical name roxadustat, is a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH). It is primarily developed for the treatment of anemia associated with chronic kidney disease (CKD) and is notable for its ability to stimulate erythropoiesis by mimicking the physiological response to hypoxia. FG 4592 works by stabilizing HIF, leading to increased production of erythropoietin and other erythropoiesis-related factors. The compound is characterized by its oral bioavailability and a favorable pharmacokinetic profile, which allows for once-daily dosing. Its mechanism of action is distinct from traditional erythropoiesis-stimulating agents, making it a novel therapeutic option. Clinical studies have demonstrated its efficacy in increasing hemoglobin levels in patients with anemia due to CKD, with a safety profile that has been generally well-tolerated. As research continues, FG 4592 represents a significant advancement in the management of anemia in patients with renal impairment.

Formula: C₁₉H₁₆N₂O₅

InChI: InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)

InChI key: InChIKey=YOZBGTLTNGAVFU-UHFFFAOYSA-N

SMILES: CC=1C2=C(C(O)=C(C(NCC(O)=O)=O)N1)C=CC(OC3=CC=CC=C3)=C2

Synonyms:

• (4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)glycine
• Asp 1517
• Glycine, N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-
• N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine
• Roxadustat
• [(4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]glycine
• [[(4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]amino]acetic acid
• FG 4592
• Roxadustat intermediates
• 2-(4-HYDROXY-1-METHYL-7-PHENOXYISOQUINOLINE-3-CARBOXAMIDO)ACETIC ACID(Roxadustat)
• [[(4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]amino]acetic acid Roxadustat (FG-4592)
• CM4309 TsOH
• Glycine, N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]- (Related Reference)
• N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine [[(4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]amino]acetic acid
• FG-4592 - Roxadustat | ASP 1517
• Roxadustat (FG-4592)
• ROXADUSTAT;ASP1517;ASP-1517;FG 4592;FG4592
• 2-(4-hydroxy-1-Methyl-7-phenoxyisoquinoline-3-carboxaMido)acetic acid
• Roxadustat Impurity ABCDEFGHJKL
• [(4-Hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid(FG-4592)
• FG-4592(ASP1517)
• CS-185
• FibroGen
• [(4-Hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid
• FG-4592 (Roxadustat)
• ASP1517
• 2-[(4-hydroxy-1-Methyl-7-phenoxyisoquinoline-3-carbonyl)aMino]acetic acid
• FG-4592 USP/EP/BP
• FG-4592/FG4592

Roxadustat

CAS: 808118-40-3

Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.

Formula: C₁₉H₁₆N₂O₅

Purity: 99% - 99.88%

Color and Shape: Solid

Molecular weight: 352.34

Ref: TM-T2515

Roxadustat

CAS: 808118-40-3

Formula: C₁₉H₁₆N₂O₅

Molecular weight: 352.35

Ref: 4Z-R-131001

N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine

Controlled Product

CAS: 808118-40-3

Applications N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine is a hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor used to increase white blood cell levels in blood and hematopoietic progenitor cells in bone marrow.

Formula: C₁₉H₁₆N₂O₅

Color and Shape: Neat

Molecular weight: 352.34

Ref: TR-H948180

Roxadustat

Controlled Product

CAS: 808118-40-3

HIF prolyl-hydroxylase inhibitor for treatment of anaemia

Formula: C₁₉H₁₆N₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 352.34 g/mol

Ref: 3D-FH32910

N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine

CAS: 808118-40-3

Formula: C₁₉H₁₆N₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 352.3407

Ref: IN-DA0036GI