CAS 808132-80-1

Guanosine,5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-methyl-, 3'-[2-cyanoethylbis(1-methylethyl)phosphoramidite] (9CI)

Description:

Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-methyl-, 3'-[2-cyanoethylbis(1-methylethyl)phosphoramidite] is a synthetic nucleoside derivative characterized by its complex structure, which includes a guanosine base linked to a phosphoramidite moiety. This compound is primarily used in the field of molecular biology, particularly in the synthesis of oligonucleotides for research and therapeutic applications. The presence of the bis(4-methoxyphenyl)phenylmethyl group enhances its stability and solubility, while the cyanoethyl phosphoramidite group facilitates the incorporation of this nucleoside into DNA strands during solid-phase synthesis. Its unique chemical properties allow for specific interactions with complementary nucleotides, making it valuable in the design of antisense oligonucleotides and other nucleic acid-based technologies. Additionally, the methylation at the N position of the guanine base may influence its binding affinity and biological activity. Overall, this compound exemplifies the intricate design of nucleoside analogs for advanced genetic research and therapeutic development.

Formula: C₄₁H₅₀N₇O₇P

Synonyms:

• N2-Methyl-Dg Cep

2''-Deoxy-5''-O-DMT-N2-methylguanosine 3''-CE phosphoramidite

CAS: 808132-80-1

Formula: C₄₁H₅₀N₇O₇P

Purity: ≥ 95%

Color and Shape: White powder or solid

Molecular weight: 783.85

Ref: 7W-GN9797

2'-Deoxy-5'-O-DMT-N2-methylguanosine 3'-CE phosphoramidite

CAS: 808132-80-1

2'-Deoxy-5'-O-DMT-N2-methylguanosine 3'-CE phosphoramidite is a novel antiviral agent that inhibits the synthesis of DNA. It is a phosphoramidite compound and is synthesized from 2'-deoxyadenosine 5'-O-(4,4'-dimethoxytrityl) N2-methylguanosine 3'-cyanoethyl phosphoramidite. This compound has been shown to inhibit the proliferation of cancer cells by inhibiting DNA synthesis. 2'-Deoxy-5'-O-DMT-N2-methylguanosine 3'-CE phosphoramidite has been shown to be an effective anticancer drug in vivo and in vitro.

Formula: C₄₁H₅₀N₇O₇P

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 783.85 g/mol

Ref: 3D-PD09171