CAS 80841-47-0

Asulacrine

Description:

Asulacrine is a synthetic compound classified as an acridine derivative, primarily known for its potential applications in medicinal chemistry, particularly in the field of cancer research. It exhibits a complex structure that contributes to its biological activity, including intercalation into DNA, which can disrupt cellular processes and inhibit tumor growth. Asulacrine has been studied for its antitumor properties and may also possess antimicrobial effects. The compound is characterized by its moderate solubility in organic solvents and limited solubility in water, which can influence its bioavailability and pharmacokinetics. Its mechanism of action typically involves the formation of reactive intermediates that can interact with cellular macromolecules. Safety and toxicity profiles are essential considerations in its application, as with many chemotherapeutic agents. Ongoing research aims to better understand its efficacy and potential side effects, as well as to explore its use in combination therapies to enhance treatment outcomes in various malignancies.

Formula: C₂₄H₂₄N₄O₄S

InChI: InChI=1S/C24H24N4O4S/c1-14-7-5-8-16-21(14)27-23-17(9-6-10-18(23)24(29)25-2)22(16)26-19-12-11-15(13-20(19)32-3)28-33(4,30)31/h5-13,28H,1-4H3,(H,25,29)(H,26,27)

InChI key: InChIKey=TWHSQQYCDVSBRK-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C(C(NC)=O)=CC=C2)N=C3C1C=CC=C3C)C4=C(OC)C=C(NS(C)(=O)=O)C=C4

Synonyms:

• CI 921
• SN 21407
• Asulacrine
• 4-Acridinecarboxamide, 9-[[2-methoxy-4-[(methylsulfonyl)amino]phenyl]amino]-N,5-dimethyl-
• 9-[[2-Methoxy-4-[(methylsulfonyl)amino]phenyl]amino]-N,5-dimethyl-4-acridinecarboxamide

Asulacrine free base

CAS: 80841-47-0

Asulacrine (CI-921; NSC-343499; SN-21407) is a topoisomerase II inhibitor disrupting DNA replication and RNA, protein synthesis in cancer treatment.

Formula: C₂₄H₂₄N₄O₄S

Color and Shape: Solid

Molecular weight: 464.54

Ref: TM-T68658