CAS 80902-28-9

Guanosine, 2′-deoxy-, 5′→P′′-ester with [P′′(S)]-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH))

Description:

Guanosine, 2′-deoxy-, 5′→P′′-ester with [P′′(S)]-thiotriphosphoric acid, identified by the CAS number 80902-28-9, is a nucleotide derivative that plays a significant role in biochemical processes. This compound features a guanosine base linked to a deoxyribose sugar, with a phosphate group esterified to the 5′ position. The presence of thiotriphosphoric acid indicates that it contains a phosphorothioate moiety, which can enhance the stability of the molecule against enzymatic degradation, making it of interest in molecular biology and therapeutic applications. The structure includes multiple phosphate groups, which contribute to its negative charge and influence its interactions with proteins and nucleic acids. This compound is often studied for its potential use in antisense oligonucleotide therapies and as a tool in gene regulation. Its unique properties, such as increased binding affinity and resistance to nucleases, make it a valuable subject of research in the fields of biochemistry and pharmacology.

Formula: C₁₀H₁₆N₅O₁₂P₃S

InChI: InChI=1S/C10H16N5O12P3S/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(25-6)2-24-30(23,31)27-29(21,22)26-28(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,31)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+,30-/m0/s1

InChI key: InChIKey=IOCRYHATDKHWPM-AVBPLPDKSA-N

SMILES: O=C1C2=C(N(C=N2)[C@@H]3O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)S)[C@@H](O)C3)NC(N)=N1

Synonyms:

• Guanosine, 2′-deoxy-, 5′→P′′-ester with [P′′(S)]-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH))
• Guanosine, 2′-deoxy-, 5′→P′′-ester with thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(S)(OH)2), (S)-

2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) lithium salt - 100mM aqueous solution

CAS: 80902-28-9

2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) lithium salt is a nucleotide analog that has been shown to inhibit the synthesis of fatty acids and proteins, as well as cause depression in mice. It also has antiviral activity against the type strain of HIV-1 (HXB2). The drug inhibits protein synthesis by preventing the incorporation of amino acids into a growing polypeptide chain. This inhibition can be reversed by adding vitamin D3 or fatty acids. 2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) lithium salt has been shown to have anti-cancer properties due to its ability to induce apoptosis, which is programmed cell death. This drug also has immune functions, such as an increase in natural killer cells and cytokines, as well as improving energy efficiency in the optical system.

Formula: C₁₀H₁₆N₅O₁₂P₃S·xLi

Purity: Min. 95%

Molecular weight: 523.25 g/mol

Ref: 3D-ND32068