CAS 80951-75-3

Cytidine, 2'-deoxy-, 5'®P''-ester with[P''(S)]-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH)) (9CI)

Description:

Cytidine 2'-deoxy-5'-phosphate ester with thiotriphosphoric acid is a nucleotide derivative characterized by its structural components, which include a cytidine base, a deoxyribose sugar, and a phosphate group. The presence of the thiotriphosphoric acid moiety introduces a sulfur atom into the phosphate backbone, which can influence the compound's biochemical properties, such as stability and reactivity. This compound is typically involved in biochemical processes, particularly in the context of nucleic acid metabolism and signaling pathways. Its unique structure may confer specific interactions with enzymes or receptors, making it of interest in biochemical research and potential therapeutic applications. The compound is soluble in aqueous solutions, and its reactivity can be modulated by the presence of functional groups. As a phosphorothioate, it may exhibit enhanced resistance to enzymatic degradation compared to its non-thioated counterparts, which is a valuable property in the development of nucleic acid-based therapeutics. Overall, this compound represents a significant area of study in molecular biology and medicinal chemistry.

Formula: C₉H₁₆N₃O₁₂P₃S

Synonyms:

• Cytidine,2'-deoxy-, 5'® P''-esterwith thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(S)(OH)2), (S)-

2'-Deoxycytidine-5'-O-(1-thiotriphosphate) lithium salt

CAS: 80951-75-3

2'-Deoxycytidine-5'-O-(1-thiotriphosphate) lithium salt (dCTPTP) is a nucleotide analogue that inhibits DNA replication. It is a substrate for DNA polymerase and can be incorporated into the growing strand of DNA. This drug has been shown to inhibit the replication of retroviruses, such as murine leukemia virus and human immunodeficiency virus type 1, in tissue cultures with relatively low concentrations. It also inhibits dengue virus when present at high concentrations. 2'-Deoxycytidine-5'-O-(1-thiotriphosphate) lithium salt has been used to study the mechanism of transcription-polymerase chain reactions by inhibiting RNA synthesis in vitro and in vivo.

Formula: C₉H₁₆N₃O₁₂P₃S·Li₄

Purity: Min. 95%

Molecular weight: 506.95 g/mol

Ref: 3D-ND58204