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CAS 81024-43-3

:

(+)-Metoprolol

Description:
(+)-Metoprolol is a selective beta-1 adrenergic receptor blocker primarily used in the treatment of hypertension, angina pectoris, and heart failure. It is a chiral compound, with the (+) designation indicating its specific optical isomer, which is the active form responsible for its therapeutic effects. The substance is typically administered in the form of its tartrate salt, enhancing its solubility and bioavailability. (+)-Metoprolol exhibits a moderate lipophilicity, allowing it to cross the blood-brain barrier, which can lead to central nervous system effects. Its mechanism of action involves the inhibition of beta-1 receptors in the heart, resulting in decreased heart rate and myocardial contractility, ultimately reducing cardiac workload and oxygen demand. The compound is generally well-tolerated, though it may cause side effects such as fatigue, dizziness, or bradycardia. Additionally, it is important to monitor patients for potential interactions with other medications, particularly those affecting heart rate or blood pressure. Overall, (+)-Metoprolol is a crucial medication in cardiovascular therapy, demonstrating efficacy and safety in various patient populations.
Formula:C15H25NO3
InChI:InChI=1/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3/t14-/m1/s1
InChI key:InChIKey=IUBSYMUCCVWXPE-CQSZACIVSA-N
SMILES:O(C[C@@H](CNC(C)C)O)C1=CC=C(CCOC)C=C1
Synonyms:
  • (+)-Metoprolol
  • (2R)-1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol
  • (R)-(+)-Metoprolol
  • 2-Propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (2R)-
  • 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (R)-
  • 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (2R)- (9CI)
  • (2R)-1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
  • Metoprolol Impurity 29
  • (R)-(+)-METOPROLOL USP/EP/BP
  • (R)-1-(isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol
  • See more synonyms
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