CAS 81069-02-5

3,3'-Dithiobis(sulfosuccinimidylpropionate)

Description:

3,3'-Dithiobis(sulfosuccinimidylpropionate), commonly referred to as DTSSP, is a crosslinking reagent widely used in biochemistry and molecular biology for the covalent linkage of proteins and other biomolecules. It features a dithiobis structure, which allows it to form stable thioether bonds with primary amines, making it particularly useful for conjugating proteins, peptides, and other amine-containing compounds. DTSSP is water-soluble and has a sulfonate group that enhances its solubility in aqueous solutions, facilitating its use in biological applications. The compound is typically employed in the formation of stable complexes for various assays, including immunoprecipitation and protein-protein interaction studies. Its ability to crosslink biomolecules can help stabilize complexes for structural studies or enhance the sensitivity of detection methods. However, care must be taken when using DTSSP, as excessive crosslinking can lead to steric hindrance and affect the biological activity of the target molecules. Proper optimization of reaction conditions is essential to achieve desired outcomes in experimental protocols.

Formula: C₁₄H₁₆N₂O₁₄S₄

InChI: InChI=1/C14H16N2O14S4/c17-9-5-7(33(23,24)25)13(21)15(9)29-11(19)1-3-31-32-4-2-12(20)30-16-10(18)6-8(14(16)22)34(26,27)28/h7-8H,1-6H2,(H,23,24,25)(H,26,27,28)

SMILES: C(CSSCCC(=O)ON1C(=O)CC(C1=O)S(=O)(=O)O)C(=O)ON1C(=O)CC(C1=O)S(=O)(=O)O

Synonyms:

• 3,3'-Dithiobis(sulfosuccinimidyl propionate)
• Dtssp
• Dtbssp
• 3-Pyrrolidinesulfonic acid, 1,1'-(dithiobis((1-oxo-3,1-propanediyl)oxy))bis(2,5-dioxo-
• 1,1'-{Disulfanediylbis[(1-Oxopropane-3,1-Diyl)Oxy]}Bis(2,5-Dioxopyrrolidine-3-Sulfonic Acid)

Dtssp

CAS: 81069-02-5

Formula: C₁₄H₁₆N₂O₁₄S₄

Purity: 90%

Molecular weight: 564.5418

Ref: IN-DA008LBB

3,3'-Dithiobis(sulphosuccinimidyl propionate)

CAS: 81069-02-5

3,3'-Dithiobis(sulphosuccinimidyl propionate)

Formula: C₁₄H₁₆N₂O₁₄S₄

Color and Shape: light tan solid

Molecular weight: 564.54g/mol

Ref: 54-BICL103

DTSSP Crosslinker

CAS: 81069-02-5

DTSSP Crosslinker

Purity: ≥98%

Molecular weight: 564.54g/mol

Ref: 54-BUP08511

DTSSP Crosslinker

CAS: 81069-02-5

DTSSP Crosslinker is a cleavable ADC linker and can be used to synthesize antibody-drug conjugates (ADCs).

Formula: C₁₄H₁₆N₂O₁₄S₄

Purity: 98.87%

Color and Shape: Solid

Molecular weight: 564.54

Ref: TM-T15179

DTSSP Crosslinker

CAS: 81069-02-5

Purity: 90%

Molecular weight: 563.948

Ref: 10-F569195

3,3’-Dithiobispropionic Acid Bis-sulfosuccinimidyl Ester Disodium Salt 90%

Controlled Product

CAS: 81069-02-5

Stability Moisture and Temperature Sensitive
Applications It is a water-soluble, thiol cleavable, homobifunctional and amine-reactive crosslinking agent.
References Bennett, K.L., et al.: Protein Sci., 9, 1503 (2000), Paine-Saunders, S., et al.: J. Biol. Chem., 277, 2089 (2002), Schaefer, L.L., et al.: J. Clin. Invest., 115, 2223 (2005),

Formula: C₁₄H₁₆N₂O₁₄S₄

Purity: 90%

Color and Shape: Neat

Molecular weight: 564.54

Ref: TR-D494330