CAS 81098-60-4: Cisapride

Description: Cisapride is a prokinetic agent primarily used to enhance gastrointestinal motility. It acts as a selective serotonin 5-HT4 receptor agonist, promoting the release of acetylcholine in the gastrointestinal tract, which facilitates peristalsis and improves gastric emptying. The chemical formula of cisapride is C23H30ClN3O4S, and it features a complex structure that includes a piperidine ring and a sulfonamide group. Cisapride is known for its ability to treat conditions such as gastroesophageal reflux disease (GERD) and functional dyspepsia. However, its use has been limited due to safety concerns, particularly the risk of serious cardiac arrhythmias associated with its interaction with certain other medications and its effect on cardiac ion channels. As a result, cisapride has been withdrawn from the market in several countries, although it may still be available in some regions under strict regulations. Its pharmacokinetics involve rapid absorption and extensive metabolism, primarily in the liver, with a relatively short half-life.

Formula: C₂₃H₂₉ClFN₃O₄

InChI: InChI=1/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)/t20-,22+/s2

InChI key: InChIKey=DCSUBABJRXZOMT-HJWBXKIQNA-N

SMILES: O=C(NC1CCN(CCCOC2=CC=C(F)C=C2)CC1OC)C=3C=C(Cl)C(N)=CC3OC

Synonyms:

• 4-amino-5-chloro-N-{(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl}-2-methoxybenzamide
• 4-amino-5-chloro-N-{(3S,4R)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl}-2-methoxybenzamide
• Acenalin
• Alimix
• Benzamide, 4-amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, rel-
• Benzamide, 4-amino-5-chloro-N-[1-[(3R,4S)-3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, rel-
• Benzamide, 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, cis-
• Cipril
• Cisad
• Cisaprid
• Cisaprida
• Coordinax
• Prepulsid
• Propulsid
• Propulsin
• R 51619
• Risamal
• T 1341
• cis-2-Methoxy-4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]benzamide
• rel-4-Amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide
• Cisapride

Cisapride

CAS: 81098-60-4

• Formula: C₂₃H₂₉ClFN₃O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 465.9455

Cisapride

CAS: 81098-60-4

Cisapride (R 51619), a 5-HT4 agonist, enhances gut peristalsis and gastric emptying, reduces reflux.

• Formula: C₂₃H₂₉ClFN₃O₄
• Purity: 99.77%
• Color and Shape: White To Slightly Biege Powder Solid
• Molecular weight: 465.95

Cisapride

CAS: 81098-60-4

• Purity: ≥98%
• Molecular weight: 465.95g/mol

Cisapride

CAS: 81098-60-4

• Formula: C₂₃H₂₉ClFN₃O₄
• Color and Shape: White To Off-White Solid
• Molecular weight: 465.96

Cisapride-d6

CAS: 81098-60-4

• Formula: C₂₃H₂₃D₆ClFN₃O₄
• Color and Shape: White To Off-White Solid
• Molecular weight: 471.99

Cisapride

CAS: 81098-60-4

• Purity: 99%
• Molecular weight: 465.95g/mol

Cisapride Monohydrate

CAS: 260779-88-2 81098-60-4

• Formula: C₂₃H₂₉ClFN₃O₄·H₂O
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 483.97

Cisapride-13C-d3

CAS: 81098-60-4

• Formula: CC₂₂H₂₆D₃ClFN₃O₄
• Molecular weight: 469.96

Cisapride

CAS: 81098-60-4

• Formula: C₂₃H₂₉ClFN₃O₄
• Color and Shape: Neat
• Molecular weight: 465.95

Cisapride Hydrate

CAS: 81098-60-4

Applications Cisapride Monohydrate is a cardioactive drug that causes prolongation of cardiac repolarization in human; …

• Formula: C₂₃H₂₉ClFN₃O₄•x(H₂O)
• Color and Shape: Neat
• Molecular weight: 465.95 + x(18.02)

Cisapride

CAS: 81098-60-4

Versatile small molecule scaffold

• Formula: C₂₃H₂₉ClFN₃O₄
• Purity: Min. 95%
• Molecular weight: 465.95 g/mol