CAS 81098-60-4

Cisapride

Description:

Cisapride is a prokinetic agent primarily used to enhance gastrointestinal motility. It acts as a selective serotonin 5-HT4 receptor agonist, promoting the release of acetylcholine in the gastrointestinal tract, which facilitates peristalsis and improves gastric emptying. The chemical formula of cisapride is C23H30ClN3O4S, and it features a complex structure that includes a piperidine ring and a sulfonamide group. Cisapride is known for its ability to treat conditions such as gastroesophageal reflux disease (GERD) and functional dyspepsia. However, its use has been limited due to safety concerns, particularly the risk of serious cardiac arrhythmias associated with its interaction with certain other medications and its effect on cardiac ion channels. As a result, cisapride has been withdrawn from the market in several countries, although it may still be available in some regions under strict regulations. Its pharmacokinetics involve rapid absorption and extensive metabolism, primarily in the liver, with a relatively short half-life.

Formula: C₂₃H₂₉ClFN₃O₄

InChI: InChI=1/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)/t20-,22+/m1/s1

InChI key: InChIKey=DCSUBABJRXZOMT-HJWBXKIQNA-N

SMILES: C(N[C@H]1[C@@H](OC)CN(CCCOC2=CC=C(F)C=C2)CC1)(=O)C3=C(OC)C=C(N)C(Cl)=C3

Synonyms:

• 4-amino-5-chloro-N-{(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl}-2-methoxybenzamide
• 4-amino-5-chloro-N-{(3S,4R)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl}-2-methoxybenzamide
• Acenalin
• Alimix
• Benzamide, 4-amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, rel-
• Benzamide, 4-amino-5-chloro-N-[1-[(3R,4S)-3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, rel-
• Benzamide, 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, cis-
• Cipril
• Cisad
• Cisaprid
• Cisaprida
• Coordinax
• Prepulsid
• Propulsid
• Propulsin
• R 51619
• Risamal
• T 1341
• cis-2-Methoxy-4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]benzamide
• rel-4-Amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide
• Cisapride
• benzamide,4-amino-5-chloro-n-(1-(3-(4-fluorophenoxy)propyl)-3-methoxy-4-piperi
• (+/-)-cis-4-amino-5-chloro-n-(1-(3-(4-fluorophenoxy)propyl)-3-methoxy-4-piperidinyl)-2-methoxybenzamide
• CISAPRIDE MONOHYDRATE
• CISAPRIDE HYDRATE
• r51619
• 4-Amino-5-chloro-N-{1[3-(4-fluorophenoxy)-propyl]-3-methoxy-4-piperidinyl}-2-methoxy-benzamide
• (+/-)-4-AMINO-5-CHLORO-N-[1-[(3R*,4S*)-3-(4-FLUOROPHENOXY)PROPYL]-3-METHOXY-4-PIPERIDINYL]-2-METHOXYBENZAMIDE
• CIS-4-AMINO-5-CHLORO-N-[1-[3-(4-FLUOROPHENOXY)PROPYL]-3-METHOXY-4-PIPERIDINYL]-2-METHOXYBENZAMIDE
• monohydrate,cis-dinyl)-2-methoxy

Cisapride Monohydrate

CAS: 260779-88-2, 81098-60-4

Formula: C₂₃H₂₉ClFN₃O₄·H₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 483.97

Ref: 3B-C3861

Cisapride

CAS: 81098-60-4

Formula: C₂₃H₂₉ClFN₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 465.9455

Ref: IN-DA00500Y

Cisapride

CAS: 81098-60-4

Cisapride (R 51619), a 5-HT4 agonist, enhances gut peristalsis and gastric emptying, reduces reflux.

Formula: C₂₃H₂₉ClFN₃O₄

Purity: 99.77%

Color and Shape: White To Slightly Biege Powder Solid

Molecular weight: 465.95

Ref: TM-T1291

Cisapride

CAS: 81098-60-4

Formula: C₂₃H₂₉ClFN₃O₄

Color and Shape: White To Off-White Solid

Molecular weight: 465.96

Ref: 4Z-C-187001

Cisapride-d6

CAS: 81098-60-4

Formula: C₂₃H₂₃D₆ClFN₃O₄

Color and Shape: White To Off-White Solid

Molecular weight: 471.99

Ref: 4Z-C-187003

Cisapride

CAS: 81098-60-4

Cisapride

Purity: 99%

Molecular weight: 465.95g/mol

Ref: 54-PC109031

Cisapride

CAS: 81098-60-4

Cisapride

Purity: ≥98%

Molecular weight: 465.95g/mol

Ref: 54-BUP15628

Cisapride-13C-d3

CAS: 81098-60-4

Formula: CC₂₂H₂₆D₃ClFN₃O₄

Molecular weight: 469.96

Ref: 4Z-C-187005

Cisapride

Controlled Product

CAS: 81098-60-4

Formula: C₂₃H₂₉ClFN₃O₄

Color and Shape: Neat

Molecular weight: 465.95

Ref: TR-C496400

Cisapride Hydrate

Controlled Product

CAS: 81098-60-4

Applications Cisapride Monohydrate is a cardioactive drug that causes prolongation of cardiac repolarization in human; selective serotonin 5-HT4 receptor agonist.
References Kuusela, J., et al.: Springerplus, 5, 1-13 (2016)

Formula: C₂₃H₂₉ClFN₃O₄•x(H₂O)

Color and Shape: Neat

Molecular weight: 465.95 + x(18.02)

Ref: TR-C496413

Cisapride

Controlled Product

CAS: 81098-60-4

Cisapride is a drug that is used for the treatment of gastrointestinal and metabolic disorders. It has been shown to be effective in treating symptoms of bowel disease and reflux, as well as preventing or reversing drug-induced constipation. Cisapride relieves symptoms by stimulating the smooth muscle cells in the gastrointestinal tract, which causes peristalsis and increases the movement of food through the intestines. Cisapride also has anti-inflammatory properties and may be used to treat other diseases such as congestive heart failure, antimicrobial agents, pharmacological agents, reaction solution, treatment trials.br>br>

Formula: C₂₃H₂₉ClFN₃O₄

Purity: Min. 95%

Molecular weight: 465.95 g/mol

Ref: 3D-GDA09860