CAS 81103-11-9

Clarithromycin

Description:

Clarithromycin is a semi-synthetic macrolide antibiotic derived from erythromycin, primarily used to treat various bacterial infections, including respiratory tract infections, skin infections, and certain types of stomach ulcers caused by Helicobacter pylori. Its chemical formula is C38H69NO13, and it features a lactone ring structure characteristic of macrolides, which contributes to its mechanism of action by inhibiting bacterial protein synthesis. Clarithromycin is known for its broad-spectrum activity against both Gram-positive and some Gram-negative bacteria, as well as atypical pathogens. It is typically administered orally and is well-absorbed in the gastrointestinal tract, with a relatively long half-life, allowing for convenient dosing schedules. The drug is metabolized in the liver, and its pharmacokinetics can be influenced by factors such as age, liver function, and concurrent medications. Common side effects may include gastrointestinal disturbances, headache, and potential interactions with other drugs due to its effects on cytochrome P450 enzymes. Overall, clarithromycin is a valuable therapeutic agent in the treatment of various infections.

Formula: C₃₈H₆₉NO₁₃

InChI: InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1

InChI key: InChIKey=AGOYDEPGAOXOCK-KCBOHYOISA-N

SMILES: O([C@H]1[C@@](OC)(C)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@](OC)(C)[C@@H](O)[C@H](C)O2)[C@@H]1C)[C@H]3[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3

Synonyms:

• (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-12,13-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (non-preferred name)
• (3R,4S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-12,13-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (non-preferred name)
• 6-O-Methylerythromycin
• 6-O-Methylerythromycin A
• A-56268
• Abbott 56268
• Antibiotic A 56268
• Antibiotic TE 31
• Biaxin
• Biaxin Xl
• Clamicin
• Claric
• Claridar
• Claripen
• Claris
• Claritek
• Clarith
• Clarithro
• Clathromycin
• Crixan
• Crixan Od
• Desclarithromycin
• Desclarithromycine
• Erythromycin, 6-O-methyl-
• Fascar
• Fromilid
• Kelamycin
• Klabax
• Klacid
• Klaribac
• Klaricid
• Klarimix
• Klarithran MR
• Macladin
• Naxy
• Oxacyclotetradecane, erythromycin deriv.
• Te 031
• Te-03
• Veclam

Clarithromycin RS

CAS: 81103-11-9

Color and Shape: White Solid Crystalline Powder

Ref: 2K-7000220021

N-Nitroso-Desmethyl Clarithromycin

CAS: 81103-11-9

Formula: C₃₇H₆₆N₂O₁₄

Color and Shape: Neat

Molecular weight: 762.94

Ref: TR-N137620

Clarithromycin

Controlled Product

CAS: 81103-11-9

Stability Store in Freezer
Applications Clarithromycin is a semi-synthetic macrolide antibiotic. Clarithromycin is a derivative of Erythromycin (E650000).
References Benson, C., et al.: Eur. J. Clin. Microbiol., 6, 173 (1987), Boyanova, L., et al.: J. Med. Microb., 61, 85 (2012), Lin, Z., et al.: Toxicol. Sci., 126, 114 (2012),

Formula: C₃₈H₆₉NO₁₃

Color and Shape: White

Molecular weight: 747.95

Ref: TR-C559750

Clarithromycin

CAS: 81103-11-9

A macrolide, broad-spectrum antibiotic that targets cytochrome P4503A4 (CYP3A4). Clarithromycin has been used to potentiate the pharmacological effects of some drugs that are metabolised by the cytochrome P450.

Formula: C₃₈H₆₉NO₁₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 747.95 g/mol

Ref: 3D-AC20469

Clarithromycin-13CD3

CAS: 81103-11-9

Clarithromycin-13CD3 is an isotopically labeled macrolide antibiotic, which is synthesized to include deuterium (D) and carbon-13 (^13C) in its molecular structure. This modified compound serves as a stable isotope-labeled standard, primarily sourced from chemical synthesis. The incorporation of these isotopes differentiates it from the naturally occurring antibiotic, enabling its use in precise analytical studies.

Formula: C₃₇CH₆₆D₃NO₁₃

Purity: Min. 95%

Molecular weight: 751.97 g/mol

Ref: 3D-AC72406

Clarithromycin - EP

CAS: 81103-11-9

A macrolide, broad-spectrum antibiotic that targets cytochrome P4503A4 (CYP3A4). Clarithromycin has been used to potentiate the pharmacological effects of some drugs that are metabolised by the cytochrome P450.

Formula: C₃₈H₆₉NO₁₃

Purity: Min. 95%

Molecular weight: 747.95 g/mol

Ref: 3D-AC171875