CAS 811803-05-1

N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide

Description:

N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide, with CAS number 811803-05-1, is a synthetic organic compound characterized by its complex molecular structure, which includes multiple aromatic rings and functional groups. This compound features a pyridinecarboxamide backbone, which is known for its potential biological activity, particularly in medicinal chemistry. The presence of a cyanocyclopentyl group and a pyridinylmethyl amino substituent suggests that it may interact with various biological targets, possibly influencing pathways related to cancer or other diseases. Its solubility, stability, and reactivity would depend on the specific conditions, such as pH and solvent, due to the presence of polar functional groups. Additionally, the compound's molecular weight, melting point, and spectral properties (such as NMR and IR) would provide further insights into its characteristics and potential applications in drug development or as a research tool in biochemistry. Overall, this compound represents a class of molecules that could be of interest in pharmaceutical research.

Formula: C₂₄H₂₃N₅O

InChI: InChI=1S/C24H23N5O/c25-17-24(11-1-2-12-24)19-5-7-20(8-6-19)29-23(30)21-4-3-13-27-22(21)28-16-18-9-14-26-15-10-18/h3-10,13-15H,1-2,11-12,16H2,(H,27,28)(H,29,30)

InChI key: InChIKey=WPEWQEMJFLWMLV-UHFFFAOYSA-N

SMILES: C(#N)C1(CCCC1)C2=CC=C(NC(=O)C3=C(NCC=4C=CN=CC4)N=CC=C3)C=C2

Synonyms:

• 3-Pyridinecarboxamide, N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-
• Apatinib
• Apatinib (YN968D1)
• Apatinib mesylate
• Aptinib
• N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide
• N-[4-(1-cyanocyclopentyl)phenyl]-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide
• Rivoceranib
• Yn 968D1
• N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]pyridine-3-carboxamide

Apatinib

CAS: 811803-05-1

Formula: C₂₄H₂₃N₅O

Molecular weight: 397.48

Ref: 4Z-A-367001

N-(4-(1-Cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide

CAS: 811803-05-1

N-(4-(1-Cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide

Purity: 99%

Molecular weight: 397.48g/mol

Ref: 54-OR1066769

Apatinib

Controlled Product

CAS: 811803-05-1

Applications Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);

Formula: C₂₄H₂₃N₅O·CH₄O₃S

Color and Shape: Neat

Molecular weight: 493.58

Ref: TR-A726150

Apatinib-d8

Controlled Product

CAS: 811803-05-1

Applications Apatinib-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is a labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);

Formula: C₂₄H₁₅D₈N₅O

Color and Shape: Neat

Molecular weight: 405.53

Ref: TR-A726153

Apatinib

CAS: 811803-05-1

Apatinib, also known as rivoceranib, is an inhibitor of the vascular endothelial growth factor receptor 2 (VEGFR2) tyrosine kinase. Apatinib targets VEGFR2 with its action and has proven to have strong anti-tumor effects in human cancers. In studies in mice, apatinib acted as an Inhibitor of VEGFR2 and played an antiangiogenic effect. Apatinib has been suggested for the treatment of ischemia-induced proliferative retinopathy and neovascular age-related macular degeneration.

Formula: C₂₄H₂₃N₅O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 397.47 g/mol

Ref: 3D-BA175030