CAS 81203-50-1

Calcitriol lactone

Description:

Calcitriol lactone, with the CAS number 81203-50-1, is a derivative of calcitriol, which is the active form of vitamin D3. This compound is characterized by its role in calcium and phosphate metabolism, influencing bone health and mineral homeostasis. Structurally, calcitriol lactone features a lactone functional group, which is a cyclic ester formed from the reaction of a hydroxyl group and a carboxylic acid. This modification can affect its biological activity and stability compared to its parent compound, calcitriol. Calcitriol lactone is typically studied for its potential therapeutic applications, particularly in conditions related to vitamin D deficiency and metabolic bone diseases. Its solubility in organic solvents and limited solubility in water are important characteristics that influence its bioavailability and pharmacokinetics. As with many vitamin D derivatives, the regulation of its synthesis and degradation in the body is crucial for maintaining proper physiological functions. Further research may explore its specific mechanisms of action and potential benefits in clinical settings.

Formula: C₂₇H₄₀O₅

InChI: InChI=1/C27H40O5/c1-16(12-21-15-27(4,31)25(30)32-21)22-9-10-23-18(6-5-11-26(22,23)3)7-8-19-13-20(28)14-24(29)17(19)2/h7-8,16,20-24,28-29,31H,2,5-6,9-15H2,1,3-4H3/b18-7+,19-8-/t16-,20-,21+,22-,23+,24+,26-,27-/m1/s1

InChI key: InChIKey=WMYIVSWWSRCZFA-RWVJFQLJSA-N

SMILES: C[C@@]12[C@](\C(=C\C=C\3/C(=C)[C@@H](O)C[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](C[C@@H]4OC(=O)[C@](C)(O)C4)C)[H])[H]

Synonyms:

• (1S,3R,5Z,7E,23S,25R)-1,3,25-trihydroxy-23,26-epoxy-9,10-secocholesta-5,7,10-trien-26-one
• (1alpha,3beta,5Z,7E,23S,25R)-1,3,23,25-Tetrahydroxy-9,10-secocholesta-5,7,10(19)-trien-26-oic gamma-lactone
• (23S,25R)-1α,25-Dihydroxyvitamin D₃ 26,23-lactone
• (3R,5S)-5-[(2R)-2-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]propyl]dihydro-3-hydroxy-3-methyl-2(3H)-furanone
• 1alpha,25-Dihydroxyvitamin D3-23,26-lactone
• 2(3H)-Furanone, 5-[(2R)-2-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]propyl]dihydro-3-hydroxy-3-methyl-, (3R,5S)-
• 9,10-Secocholesta-5,7,10(19)-trien-26-oic acid, 1,3,23,25-tetrahydroxy-, γ-lactone, (1α,3β,5Z,7E,23S,25R)-
• Calcitriol lactone
• (23S,25R)-1α,25-Dihydroxyvitamin D3 26,23-lactone
• (3R,5S)-5-[(2R)-2-[(1R,3aR,4E,7aR)-4-[(2Z)-2-[(3S,5S)-3,5-dihydroxy-2-methylidene-cyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]propyl]-3-hydroxy-3-methyl-oxolan-2-one
• (23S,25R)-1α,25-(OH)2D3-26,23-Lactone
• (5Z,7E,23S,25R)-1α,3β,23,25-Tetrahydroxy-9,10-secocholesta-5,7,10(19)-triene-26-oic acid γ-lactone
• (23S,25R)-1α,25-DihydroxyvitaminD3 26,23-lactone
• (1S,23S,25R)-1,25-Dihydroxy-23,26-epoxy-26-oxocholecalciferol
• 23S,25R-1α,25-(OH)2-D3-26,23-Lactone

Calcitriol lactone

CAS: 81203-50-1

Calcitriol lactone (1α,25-Dihydroxyvitamin D3-26,23-lactone), a vitamin D3 metabolite, serves as the active form of vitamin D, influencing bone health, cell differentiation, and immune function.

Formula: C₂₇H₄₀O₅

Molecular weight: 444.60

Ref: TM-T88104

Calcitriol Lactone

CAS: 81203-50-1

Formula: C₂₇H₄₀O₅

Molecular weight: 444.61

Ref: 4Z-C-129056

Calcitriol Lactone

Controlled Product

CAS: 81203-50-1

Formula: C₂₇H₄₀O₅

Color and Shape: Neat

Molecular weight: 444.603

Ref: TR-C144515

Calcitriol Lactone

CAS: 81203-50-1

Formula: C₂₇H₄₀O₅

Molecular weight: 444.61

Ref: ST-EA-CP-C49017