CAS 81256-81-7

[8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-1-yl]methyl beta-D-glucopyranosiduronic acid

Description:

The chemical substance known as [8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-1-yl]methyl beta-D-glucopyranosiduronic acid, with the CAS number 81256-81-7, is a complex organic compound that features a unique combination of a benzodiazepine structure and a glucopyranosiduronic acid moiety. This compound is characterized by the presence of a chloro group and a fluorophenyl substituent, which may influence its pharmacological properties and interactions. The imidazo-benzodiazepine core suggests potential activity in the central nervous system, possibly as an anxiolytic or sedative agent. The glucopyranosiduronic acid component may enhance solubility and bioavailability, potentially affecting its metabolic pathways. Overall, the structural complexity and functional groups present in this compound indicate that it may exhibit interesting biological activities, warranting further investigation in medicinal chemistry and pharmacology. However, specific data regarding its efficacy, safety, and mechanism of action would require detailed experimental studies.

Formula: C₂₄H₂₁ClFN₃O₇

InChI: InChI=1/C24H21ClFN3O7/c25-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)26)28-9-12-8-27-17(29(12)16)10-35-24-21(32)19(30)20(31)22(36-24)23(33)34/h1-8,19-22,24,30-32H,9-10H2,(H,33,34)/t19-,20-,21+,22-,24+/m0/s1

1'-Hydroxy Midazolam-β-D-glucuronide

Controlled Product

CAS: 81256-81-7

Applications The major metabolite of Midazolam (M343000(P)). Midazolam is an anesthetic; anticonvulsant; sedative; hypnotic. It is a positive allosteric modulator of the GABAA receptor.
References Dundee, J. W., et al.: Drugs, 28, 519 (1984), Lahat, E., et al.: Br. Med. J., 321, 83 (2000)

Formula: C₂₄H₂₁ClFN₃O₇

Color and Shape: White To Off-White

Molecular weight: 517.89

Ref: TR-H948430

1'-Hydroxy Midazolam-β-D-glucuronide-d5

Controlled Product

CAS: 81256-81-7

Formula: C₂₄H₁₆D₅ClFN₃O₇

Color and Shape: White To Off-White

Molecular weight: 522.92

Ref: TR-H948432

1’-Hydroxy Midazolam-b-D-glucuronide (1 mg/ml in Methanol)

Controlled Product

CAS: 81256-81-7

Formula: C₂₄H₂₁ClFN₃O₇

Color and Shape: Single Solution

Molecular weight: 517.89

Ref: TR-KIT1890

1-Hydroxymidazolam-b-D-glucuronide

Controlled Product

CAS: 81256-81-7

1-Hydroxymidazolam-b-D-glucuronide (1HMG) is a metabolite of diazepam. It has been shown to be a potent inducer of CYP3A4, which is an enzyme responsible for the metabolism of many drugs. 1HMG has also been shown to increase the elimination rate of diazepam and reduce its half-life. The detection limit for 1HMG in blood is about 0.1 µg/L and it can be detected in serum up to 20 days after administration. It has been used as a biomarker for diazepam exposure in children and adults with depression or other mental illnesses. This drug also has depressant effects on the CNS and may be used as medicines for this purpose.

Formula: C₂₄H₂₁ClFN₃O₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 517.89 g/mol

Ref: 3D-MH11754

1'-Hydroxy Midazolam-β-D-Glucuronide

CAS: 81256-81-7

Formula: C₂₄H₂₁ClFN₃O₇

Molecular weight: 517.9

Ref: ST-EA-CP-M85021