CAS 81306-64-1

parathyroid hormone fragment (13-34)*human

Description:

Parathyroid hormone fragment (13-34) is a synthetic peptide derived from the human parathyroid hormone (PTH), specifically representing the amino acid sequence from positions 13 to 34. This fragment retains some biological activity associated with the regulation of calcium and phosphate metabolism, primarily influencing bone remodeling and renal function. It is known to interact with specific receptors in target tissues, promoting osteoblast activity and enhancing renal tubular reabsorption of calcium. The CAS number 81306-64-1 identifies this specific peptide, which is often utilized in research and therapeutic contexts, particularly in studies related to osteoporosis and metabolic bone diseases. Characteristically, this fragment is soluble in aqueous solutions and can be synthesized through solid-phase peptide synthesis techniques. Its stability, bioactivity, and potential therapeutic applications make it a subject of interest in endocrinology and pharmacology. However, as with any peptide, its efficacy and safety profile would need to be thoroughly evaluated in clinical settings.

Formula: C₁₀₉H₁₈₂N₃₆O₂₉S

InChI: InChI=1/C109H182N36O29S/c1-55(2)41-71(96(162)132-68(30-32-81(114)147)93(159)139-78(49-85(152)153)103(169)145-87(59(9)10)106(172)141-75(46-62-51-122-54-126-62)100(166)138-76(47-82(115)148)101(167)142-79(107(173)174)44-60-23-13-12-14-24-60)135-91(157)65(27-17-20-37-112)128-89(155)64(26-16-19-36-111)127-90(156)66(28-21-38-123-108(117)118)130-97(163)73(43-57(5)6)140-105(171)86(58(7)8)144-95(161)67(29-22-39-124-109(119)120)129-92(158)69(31-33-84(150)151)131-94(160)70(34-40-175-11)133-104(170)80(52-146)143-102(168)77(48-83(116)149)137-98(164)72(42-56(3)4)136-99(165)74(45-61-50-121-53-125-61)134-88(154)63(113)25-15-18-35-110/h12-14,23-24,50-51,53-59,63-80,86-87,146H,15-22,25-49,52,110-113H2,1-11H3,(H2,114,147)(H2,115,148)(H2,116,149)(H,121,125)(H,122,126)(H,127,156)(H,128,155)(H,129,158)(H,130,163)(H,131,160)(H,132,162)(H,133,170)(H,134,154)(H,135,157)(H,136,165)(H,137,164)(H,138,166)(H,139,159)(H,140,171)(H,141,172)(H,142,167)(H,143,168)(H,144,161)(H,145,169)(H,150,151)(H,152,153)(H,173,174)(H4,117,118,123)(H4,119,120,124)/t63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,86-,87-/m0/s1

SMILES: CC(C)C[C@@H](C(=N[C@@H](CCC(=N)O)C(=N[C@@H](CC(=O)O)C(=N[C@@H](C(C)C)C(=N[C@@H](Cc1cnc[nH]1)C(=N[C@@H](CC(=N)O)C(=N[C@@H](Cc1ccccc1)C(=O)O)O)O)O)O)O)O)N=C([C@H](CCCCN)N=C([C@H](CCCCN)N=C([C@H](CCCNC(=N)N)N=C([C@H](CC(C)C)N=C([C@H](C(C)C)N=C([C@H](CCCNC(=N)N)N=C([C@H](CCC(=O)O)N=C([C@H](CCSC)N=C([C@H](CO)N=C([C@H](CC(=N)O)N=C([C@H](CC(C)C)N=C([C@H](Cc1cnc[nH]1)N=C([C@H](CCCCN)N)O)O)O)O)O)O)O)O)O)O)O)O)O

Synonyms:

• pTH (13-34) (human)
• H-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH

pTH (13-34) (human)

CAS: 81306-64-1

Bachem ID: 4014782.

Formula: C₁₂₅H₁₉₉N₃₉O₃₃S

Purity: 97.9%

Color and Shape: White Lyophilisate

Molecular weight: 2808.26

Ref: 01-4014782

Parathyroid Hormone (Human, 13-34)

CAS: 81306-64-1

Amino acids 13-34 of the Parathyroid Hormone (PTH) which is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications and is available as a 0.5mg vial.

Formula: C₁₂₅H₁₉₉N₃₉O₃₃S

Purity: Min. 95%

Molecular weight: 2,808.2 g/mol

Ref: 3D-PTH-4106-V

pTH (13-34) (human)

CAS: 81306-64-1

Please enquire for more information about pTH (13-34) (human) including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₁₂₅H₁₉₉N₃₉O₃₃S

Purity: Min. 95%

Molecular weight: 2,808.23 g/mol

Ref: 3D-FP109194