CAS 81377-02-8

Seglitide

Description:

Seglitide, with the CAS number 81377-02-8, is a synthetic peptide that functions primarily as a glucagon-like peptide-1 (GLP-1) receptor agonist. It is designed to mimic the action of the naturally occurring GLP-1 hormone, which plays a crucial role in glucose metabolism and insulin secretion. Seglitide is characterized by its ability to enhance insulin release in response to elevated blood glucose levels, thereby aiding in the management of type 2 diabetes. Additionally, it may contribute to weight loss by promoting satiety and reducing appetite. The substance is typically administered via injection and has a relatively short half-life, necessitating regular dosing for sustained effects. Its pharmacological profile includes potential cardiovascular benefits and a low risk of hypoglycemia when used appropriately. As with other GLP-1 receptor agonists, side effects may include gastrointestinal disturbances, such as nausea or vomiting, particularly during the initial stages of treatment. Overall, Seglitide represents a promising therapeutic option in the landscape of diabetes management.

Formula: C₄₄H₅₆N₈O₇

InChI: InChI=1/C44H56N8O7/c1-26(2)38-43(58)50-37(23-28-12-6-5-7-13-28)44(59)52(4)27(3)39(54)48-35(22-29-17-19-31(53)20-18-29)41(56)49-36(24-30-25-46-33-15-9-8-14-32(30)33)42(57)47-34(40(55)51-38)16-10-11-21-45/h5-9,12-15,17-20,25-27,34-38,46,53H,10-11,16,21-24,45H2,1-4H3,(H,47,57)(H,48,54)(H,49,56)(H,50,58)(H,51,55)/t27-,34-,35-,36+,37-,38-/m0/s1

Synonyms:

• Seglitide [INN]
• Seglitida
• Seglitida [Spanish]
• Seglitidum
• Seglitidum [Latin]
• Cyclic(N-methyl-L-alanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl)
• Cyclo(N-methyl-L-alanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl)
• N-Methylcyclo(L-Ala-L-Tyr-D-Trp-L-Lys-L-Val-L-Phe-)
• L-363586
• MK 678
• CYCLIC(N-METHYL-ALA-TYR-D-TRP-LYS-VAL-PHE)
• SEGLITIDE
• Cyclic(N-methyl-Ala-Tyr-D-Trp-Lys-Val-Phe), MK 678
• Cyclo(L-Tyr-D-Trp-L-Lys-L-Val-L-Phe-N-methyl-L-Ala-)
• M.W. 808.98 C44H56N8O7
• N-Methyl-cyclo(L-Ala-L-Tyr-D-Trp-L-Lys-L-Val-L-Phe-)

Seglitide

CAS: 81377-02-8

Peptide agonist targets sst2/sst5 receptors. IC50/Kd: sst1 >1000, sst2 = 0.2-1.5, sst3 = 27-36, sst4 >127, sst5 = 0.06-23 nM.

Formula: C₄₄H₅₆N₈O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 808.98

Ref: TM-TP2122