CAS 81447-78-1

Levlofexidine

Description:

Levofexidine, with the CAS number 81447-78-1, is a chemical compound primarily recognized for its role as an alpha-2 adrenergic agonist. It is structurally related to other compounds in the class of imidazoline derivatives. Levofexidine is characterized by its ability to modulate neurotransmitter release, particularly norepinephrine, which contributes to its pharmacological effects. This compound is often investigated for its potential therapeutic applications, particularly in the management of withdrawal symptoms in opioid dependence and other conditions related to autonomic dysregulation. Its mechanism of action involves binding to alpha-2 adrenergic receptors in the central nervous system, leading to decreased sympathetic outflow and reduced anxiety. Additionally, levofexidine may exhibit sedative properties, making it a candidate for further research in various clinical settings. As with many pharmacological agents, the safety profile, dosage, and specific therapeutic uses are determined through clinical studies and regulatory evaluations.

Formula: C₁₁H₁₂Cl₂N₂O

InChI: InChI=1/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15)/t7-/m1/s1

SMILES: C[C@H](C1=NCCN1)Oc1c(cccc1Cl)Cl

Synonyms:

• Levlofexidine [INN]
• (-)-(R)-2-(1-(2,6-Dichlorophenoxy)ethyl)-2-imidazoline
• Unii-5Spw497X0Z
• 2-[(1S)-1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole
• 2-[(1R)-1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole

(R)-Lofexidine

CAS: 81447-78-1

Formula: C₁₁H₁₂Cl₂N₂O

Molecular weight: 259.13

Ref: 4Z-L-206003

(R)-Lofexidine

CAS: 81447-78-1

Alpha-2-adrenergic receptor agonist; used for the treatment of opiate withdrawal

Formula: C₁₁H₁₂Cl₂N₂O

Purity: Min. 95%

Molecular weight: 259.13 g/mol

Ref: 3D-FL24918

(R)-Lofexidine

Controlled Product

CAS: 81447-78-1

Applications The R-enantiomer of Lofexidine. α2-Adrenoceptor agonist related structurally to Clonidine. Used in treatment of opioid withdrawal symptoms; antihypertensive.
References Velly, J., et al.: J. Pharmacol., 8, 351 (1977), Jarrot, B., et al.: Biochem. Pharmacol., 28, 141 (1979), Birch, P., at al.: Brit. J. Pharmacol., 68, 107 (1980),

Formula: C₁₁H₁₂Cl₂N₂O

Color and Shape: Neat

Molecular weight: 259.13

Ref: TR-L469395