CAS 81447-79-2

Dexlofexidine

Description:

Dexlofexidine, with the CAS number 81447-79-2, is a selective alpha-2 adrenergic agonist primarily used for its sedative and analgesic properties. It is a derivative of the well-known drug dexmedetomidine and is characterized by its ability to modulate neurotransmitter release, particularly norepinephrine, leading to sedation and analgesia without significant respiratory depression. Dexlofexidine exhibits a high affinity for alpha-2 adrenergic receptors, which contributes to its effectiveness in reducing anxiety and promoting sedation in clinical settings. The substance is typically administered intravenously and is utilized in various medical procedures, particularly in intensive care and anesthesia. Its pharmacokinetic profile includes rapid onset and a relatively short duration of action, making it suitable for short-term sedation. Additionally, it has been studied for its potential neuroprotective effects and its role in managing withdrawal symptoms in certain patient populations. As with any medication, its use is accompanied by potential side effects, including hypotension and bradycardia, necessitating careful monitoring during administration.

Formula: C₁₁H₁₂Cl₂N₂O

Synonyms:

• Dexlofexidine [INN]
• (+)-(S)-2-(1-(2,6-Dichlorophenoxy)ethyl)-2-imidazoline
• Dexlofexidinum
• Unii-Vxj7Z24Rn1

(S)-Lofexidine

CAS: 81447-79-2

Formula: C₁₁H₁₂Cl₂N₂O

Molecular weight: 259.13

Ref: 4Z-L-206004

(S)-Lofexidine

Controlled Product

CAS: 81447-79-2

Applications The S-enantiomer of Lofexidine. α2-Adrenoceptor agonist related structurally to Clonidine. Used in treatment of opioid withdrawal symptoms; antihypertensive.
References Velly, J., et al.: J. Pharmacol., 8, 351 (1977), Jarrot, B., et al.: Biochem. Pharmacol., 28, 141 (1979), Birch, P., at al.: Brit. J. Pharmacol., 68, 107 (1980),

Formula: C₁₁H₁₂Cl₂N₂O

Color and Shape: Neat

Molecular weight: 259.13

Ref: TR-L469400

Dexlofexidine Free Base

CAS: 81447-79-2

Dexlofexidine Free Base is a less potent (+) isomer of lofexidine and an alpha-2 adrenoceptor agonist, 10x weaker than levlofexidine.

Formula: C₁₁H₁₂Cl₂N₂O

Color and Shape: Solid

Molecular weight: 259.13

Ref: TM-T68649