CAS 81496-82-4
:Dihydroartemisinin
Description:
Dihydroartemisinin is a semi-synthetic derivative of artemisinin, which is derived from the sweet wormwood plant, Artemisia annua. It is primarily known for its potent antimalarial properties and is used in the treatment of malaria, particularly in combination therapies to enhance efficacy and reduce resistance. The compound features a unique endoperoxide bridge in its structure, which is crucial for its biological activity. Dihydroartemisinin is characterized by its relatively low solubility in water but good solubility in organic solvents, which influences its formulation in pharmaceutical preparations. It exhibits a rapid onset of action against Plasmodium species, the parasites responsible for malaria, and is generally well-tolerated with a favorable safety profile. Additionally, research has indicated potential applications beyond malaria, including anticancer properties, although further studies are needed to fully understand its mechanisms and efficacy in these areas. Overall, dihydroartemisinin remains a vital component in global malaria treatment strategies.
Formula:C15H24O5
InChI:InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14-,15-/m1/s1
InChI key:InChIKey=BJDCWCLMFKKGEE-ISOSDAIHSA-N
SMILES:C[C@@H]1[C@]2([C@]34[C@@](O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])(O[C@@H]1O)[H])[H]
Synonyms:- 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol, decahydro-3,6,9-trimethyl-, [3R-(3α,5aβ,6β,8aβ,9α,10α,12β,12aR*)]-
- (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol
- 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol, decahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10S,12R,12aR)-
- Dihydroartemisinin
- Dihydroartemisinine
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