CAS 817194-38-0

GSK180736A

CAS: 817194-38-0

Formula: C₁₉H₁₆FN₅O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 365.3610

Ref: IN-DA01EO6R

4-(4-Fluorophenyl)-N-(1H-Indazol-5-Yl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxamide

CAS: 817194-38-0

4-(4-Fluorophenyl)-N-(1H-Indazol-5-Yl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxamide

Purity: 98%

Molecular weight: 365.36g/mol

Ref: 54-PC108993

GSK180736A

CAS: 817194-38-0

GSK180736A

Purity: ≥98%

Molecular weight: 365.36g/mol

Ref: 54-BUP11975

GSK180736A

CAS: 817194-38-0

GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).

Formula: C₁₉H₁₆FN₅O₂

Purity: 98.38% - 98.98%

Color and Shape: Solid

Molecular weight: 365.36

Ref: TM-T3513

GSK180736A

CAS: 817194-38-0

GSK180736A is a potent and selective small-molecule inhibitor of the serine/threonine kinase PKCδ with in vitro IC50 values of 0.5 nM. GSK180736A inhibits the phosphorylation of PKCδ substrates by PKCδ and prevents its nuclear translocation, leading to inhibition of cardiac hypertrophy and insulin resistance. The IC50 value for inhibition of PKCδ activity was determined to be 0.5 nM in an internalization assay using cells expressing GFP-tagged human PKCδ (hPKCδ). In addition, GSK180736A inhibits the phosphorylation of PKCα and ε at a concentration of 1 μM in an in vitro kinase assay. These results suggest that GSK180736A is a selective inhibitor for the kinase domain of PKCδ and other members of the PKC family

Formula: C₁₉H₁₆FN₅O₂

Purity: Min. 95%

Molecular weight: 365.36 g/mol

Ref: 3D-SHB19438