CAS 817204-33-4

2′-Deoxy-2′-fluoro-2′-C-methylcytidine

Description:

2′-Deoxy-2′-fluoro-2′-C-methylcytidine is a modified nucleoside analog that belongs to the class of cytidine derivatives. It features a fluorine atom at the 2′ position of the ribose sugar and a methyl group at the 2′-C position, which enhances its stability and bioactivity compared to natural nucleosides. This compound is of particular interest in medicinal chemistry and virology, as it exhibits antiviral properties, particularly against certain RNA viruses. The presence of the fluorine atom can influence the compound's interaction with nucleic acid targets, potentially improving its efficacy as an antiviral agent. Additionally, the structural modifications may enhance its resistance to enzymatic degradation, making it a valuable candidate for therapeutic applications. The compound's unique characteristics, including its solubility, binding affinity, and metabolic stability, are critical for its function in biological systems and its potential use in drug development. Overall, 2′-Deoxy-2′-fluoro-2′-C-methylcytidine represents a significant advancement in the design of nucleoside analogs for therapeutic purposes.

Formula: C₁₀H₁₄FN₃O₄

InChI: InChI=1S/C10H14FN3O4/c1-10(11)7(16)5(4-15)18-8(10)14-3-2-6(12)13-9(14)17/h2-3,5,7-8,15-16H,4H2,1H3,(H2,12,13,17)/t5-,7-,8-,10-/m1/s1

InChI key: InChIKey=NYPIRLYMDJMKGW-VPCXQMTMSA-N

SMILES: C[C@]1(F)[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)C=C2

Synonyms:

• (2′R)-2′-Deoxy-2′-fluoro-2′-methylcytidine
• Cytidine, 2′-deoxy-2′-fluoro-2′-methyl-, (2′R)-
• Psi 6130
• R 1656
• 2′-Deoxy-2′-fluoro-2′-C-methylcytidine

2'-deoxy-2'-fluoro-2'-C-methylcytidine

CAS: 817204-33-4

Formula: C₁₀H₁₄FN₃O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 259.2343

Ref: IN-DA00G3PL

PSI-6130

CAS: 817204-33-4

PSI-6130

Purity: ≥98%

Molecular weight: 259.23g/mol

Ref: 54-BUP12060

PSI-6130

CAS: 817204-33-4

PSI-6130 (R 1656) is a potent and selective HCV NS5B polymerase inhibitor. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM.

Formula: C₁₀H₁₄FN₃O₄

Purity: 98.63% - 99.79%

Color and Shape: Solid

Molecular weight: 259.23

Ref: TM-T7607

Sofosbuvir Impurity 115

CAS: 817204-33-4

Formula: C₁₀H₁₄FN₃O₄

Molecular weight: 259.24

Ref: 4Z-S-055124

PSI 6130

Controlled Product

CAS: 817204-33-4

Applications PSI-6130 is an experimental treatment for hepatitis C. PSI-6130 is a member of a class of antiviral drugs known as nucleoside polymerase inhibitors. PSI-6130 inhibits the hepatitis C virus RNA dependant RNA polymerase called NS5B.
References Clark, J., et al.: J. Med. Chem., 48, 5504 (2005); Stuyver, L., et al.: Antiviral Chem. Chem., 17, 79 (2006)

Formula: C₁₀H₁₄FN₃O₄

Color and Shape: Neat

Molecular weight: 259.23

Ref: TR-P839680

Sofosbuvir Impurity 115

CAS: 817204-33-4

Formula: C₁₀H₁₄FN₃O₄

Molecular weight: 259.24

Ref: ST-EA-CP-S45085

PSI-6130

CAS: 817204-33-4

Purity: 98%

Molecular weight: 259.24

Ref: 10-F407885

2'-Deoxy-2'-fluoro-2'-C-methylcytidine

CAS: 817204-33-4

2'-Deoxy-2'-fluoro-2'-C-methylcytidine is a nucleoside analog with modifications on both the sugar and the nucleobase. It is a derivative of cytidine, with fluorine attached to the 2' carbon of the sugar (deoxyribose) and a methyl group at the 2' carbon of the sugar as well. These modifications provide the compound with unique properties, such as potnetial increased resistance to enzymatic degradation, which can make it useful in antiviral and anticancer applications.

Formula: C₁₀H₁₄FN₃O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 259.23 g/mol

Ref: 3D-ND28816

1’-epi-PSI-6130

Controlled Product

CAS: 817204-33-4

Formula: C₁₀H₁₄FN₃O₄

Color and Shape: Neat

Molecular weight: 259.23

Ref: TR-P839685