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CAS 81771-19-9

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Lolitrem B

Description:
Lolitrem B is a mycotoxin produced by certain species of fungi, particularly those in the genus *Neotyphodium*, which are often associated with grasses. This compound is known for its neurotoxic properties, affecting the central nervous system of mammals, including livestock. Lolitrem B is characterized by its complex molecular structure, which includes multiple rings and functional groups that contribute to its biological activity. It is typically found in contaminated forage, leading to conditions such as ryegrass staggers in animals that consume affected plants. The toxicity of Lolitrem B is attributed to its ability to interfere with neurotransmitter release, resulting in symptoms such as tremors, incoordination, and other neurological disturbances. Due to its potential health risks, monitoring and management of forage quality in agricultural settings are crucial to prevent exposure. Additionally, research continues to explore the mechanisms of its toxicity and potential methods for detoxification or mitigation in affected environments.
Formula:C42H55NO7
InChI:InChI=1S/C42H55NO7/c1-20(2)17-28-47-32-34(38(7,8)48-28)46-27-14-15-39(9)40(10)21(13-16-41(39,45)42(27)35(32)49-42)18-24-29-23-19-25-30(37(5,6)50-36(25,3)4)31(44)22(23)11-12-26(29)43-33(24)40/h11-12,17,21,25,27-28,30,32,34-35,43,45H,13-16,18-19H2,1-10H3/t21-,25+,27-,28-,30-,32+,34-,35+,39+,40+,41-,42-/m0/s1
InChI key:InChIKey=HGBZMCXKHKZYBF-WZGHVFPCSA-N
SMILES:O[C@]12[C@]34[C@](O3)([C@]5([C@](O[C@]4(CC[C@]1(C)[C@@]6(C)C7=C(C[C@@]6(CC2)[H])C=8C(N7)=CC=C9C8C[C@@]%10([C@@](C9=O)(C(C)(C)OC%10(C)C)[H])[H])[H])(C(C)(C)O[C@@H](C=C(C)C)O5)[H])[H])[H]
Synonyms:
  • 7H-[1,3]Dioxino[5′′,4′′:2′,3′]oxireno[4′,4′a][1]benzopyrano[5′,6′:6,7]indeno[1,2-b]isobenzofuro[5,6-e]indol-13(8H)-one, 1,4a,4b,5b,6,7a,9,9a,10,12,12a,16,16b,16c,17,18,18a,19a-octadecahydro-5b-hydroxy-1,1,10,10,12,12,16b,16c-octamethyl-3-(2-methyl-1-propen-1-yl)-, (3S,4aR,4bR,5aS,5bS,7aS,9aR,12aR,16bS,16cR,18aS,19aS)-
  • Lolitrem B
  • 7H-[1,3]Dioxino[5′′,4′′:2′,3′]oxireno[4′,4′a][1]benzopyrano[5′,6′:6,7]indeno[1,2-b]isobenzofuro[5,6-e]indol-13(8H)-one, 1,4a,4b,5b,6,7a,9,9a,10,12,12a,16,16b,16c,17,18,18a,19a-octadecahydro-5b-hydroxy-1,1,10,10,12,12,16b,16c-octamethyl-3-(2-methyl-1-propenyl)-, (3S,4aR,4bR,5aS,5bS,7aS,9aR,12aR,16bS,16cR,18aS,19aS)-
  • 7H-[1,3]Dioxino[5′′,4′′:2′,3′]oxireno[4′,4′a][1]benzopyrano[5′,6′:6,7]indeno[1,2-b]isobenzofuro[5,6-e]indol-13(8H)-one, 1,4a,4b,5b,6,7a,9,9a,10,12,12a,16,16b,16c,17,18,18a,19a-octadecahydro-5b-hydroxy-1,1,10,10,12,12,16b,16c-octamethyl-3-(2-methyl-1-propenyl)-, [3S-(3α,4aβ,4bβ,5aR*,5bα,7aβ,9aβ,12aα,16bα,16cβ,18aα,19aα)]-
  • (3S,4aR,4bR,5aS,5bS,7aS,9aR,12aR,16bS,16cR,18aS,19aS)-1,4a,4b,5b,6,7a,9,9a,10,12,12a,16,16b,16c,17,18,18a,19a-Octadecahydro-5b-hydroxy-1,1,10,10,12,12,16b,16c-octamethyl-3-(2-methyl-1-propen-1-yl)-7H-[1,3]dioxino[5′′,4′′:2′,3′]oxireno[4′,4′a][1]benzopyrano[5′,6′:6,7]indeno[1,2-b]isobenzofuro[5,6-e]indol-13(8H)-one
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