CAS 81794-13-0

5′-O-[Bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine

Description:

5′-O-[Bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine, with the CAS number 81794-13-0, is a modified nucleoside derivative of adenosine. This compound features a complex structure that includes a 5′-O-bis(4-methoxyphenyl)phenylmethyl group and a 2′-O-(1,1-dimethylethyl)dimethylsilyl moiety, which enhance its stability and solubility. The presence of methoxy groups contributes to its lipophilicity, potentially influencing its biological activity and interaction with cellular targets. The silyl group provides protection against hydrolysis, making it more resistant to enzymatic degradation. Such modifications are often employed to improve the pharmacokinetic properties of nucleosides, allowing for better absorption and longer half-life in biological systems. This compound may be of interest in biochemical research, particularly in studies involving nucleoside analogs and their applications in drug development or molecular biology. Its unique structural features suggest potential utility in therapeutic contexts, although specific biological activities would require further investigation.

Formula: C₃₇H₄₅N₅O₆Si

InChI: InChI=1S/C37H45N5O6Si/c1-36(2,3)49(6,7)48-32-31(43)29(47-35(32)42-23-41-30-33(38)39-22-40-34(30)42)21-46-37(24-11-9-8-10-12-24,25-13-17-27(44-4)18-14-25)26-15-19-28(45-5)20-16-26/h8-20,22-23,29,31-32,35,43H,21H2,1-7H3,(H2,38,39,40)/t29-,31-,32-,35-/m1/s1

InChI key: InChIKey=WBXYUFMFVHCXRR-QSYCCZFCSA-N

SMILES: C(OC[C@H]1O[C@H]([C@H](O[Si](C(C)(C)C)(C)C)[C@@H]1O)N2C=3C(N=C2)=C(N)N=CN3)(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6

Synonyms:

• Adenosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-
• 5′-O-[Bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine

2''-O-tert-Butyldimethylsilyl-5''-O-DMT-adenosine

CAS: 81794-13-0

Ref: 7W-GN6210

5'-O-(4,4'-Dimethoxytrityl)-2'-O-t-butyldimethylsilyl adenosine

CAS: 81794-13-0

Nucleoside; Used for RNA synthesis and special nucleoside modification

Formula: C₃₇H₄₅N₅O₆Si

Color and Shape: Solid

Molecular weight: 683.87

Ref: TM-TNU0600

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-adenosine

CAS: 81794-13-0

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-adenosine is a modified nucleoside that is used to synthesize oligonucleotides. It is a phosphoramidite, and can be used in the synthesis of DNA or RNA. 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-adenosine is an antiviral agent that has been shown to have anticancer activity in animal models. It has been shown to inhibit the production of tumor necrosis factor alpha (TNFα) and serum enzymes, such as dismutase activity, in mice with lung cancer. This drug also has a toxic effect on respiratory system cells, which may be due to its ability to induce apoptosis.

Purity: Min. 95%

Ref: 3D-NB15553