CAS 81820-68-0

1-Phthalidyl-5-fluorouracil

Description:

1-Phthalidyl-5-fluorouracil, with the CAS number 81820-68-0, is a synthetic derivative of the well-known chemotherapeutic agent 5-fluorouracil (5-FU). This compound features a phthalidyl group, which enhances its pharmacological properties. It is characterized by its ability to inhibit thymidylate synthase, an enzyme critical for DNA synthesis, thereby exerting antitumor effects. The presence of the fluorine atom in its structure contributes to its increased potency and selectivity against cancer cells. 1-Phthalidyl-5-fluorouracil is typically studied for its potential applications in cancer therapy, particularly in the treatment of solid tumors. Its solubility and stability in various solvents can vary, influencing its bioavailability and therapeutic efficacy. Additionally, like other fluoropyrimidines, it may exhibit side effects related to its mechanism of action, including effects on rapidly dividing normal cells. Ongoing research aims to better understand its pharmacokinetics, optimal dosing regimens, and potential combination therapies to enhance its anticancer activity while minimizing toxicity.

Formula: C₁₂H₇FN₂O₄

InChI: InChI=1S/C12H7FN2O4/c13-8-5-15(12(18)14-9(8)16)10-6-3-1-2-4-7(6)11(17)19-10/h1-5,10H,(H,14,16,18)

InChI key: InChIKey=JADGCGSQDUSAED-UHFFFAOYSA-N

SMILES: O=C1N(C2C=3C(C(=O)O2)=CC=CC3)C=C(F)C(=O)N1

Synonyms:

• 1-(1,3-Dihydro-3-oxo-1-isobenzofuranyl)-5-fluoro-2,4(1H,3H)-pyrimidinedione
• 1-Phthalidyl-5-fluorouracil
• 2,4(1H,3H)-pyrimidinedione, 1-(1,3-dihydro-3-oxo-1-isobenzofuranyl)-5-fluoro-
• N₁-Phthalidyl-5-fluorouracil
• N1-Phthalidyl-5-fluorouracil