CAS 81840-58-6

Spirendolol

Description:

Spirendolol is a chemical compound classified as a beta-blocker, primarily used in the treatment of hypertension and certain heart conditions. It is characterized by its ability to selectively block beta-adrenergic receptors, which helps in reducing heart rate and blood pressure. Spirendolol exhibits both beta-1 and beta-2 adrenergic receptor antagonism, contributing to its therapeutic effects. The compound has a unique molecular structure that includes a phenolic group, which is essential for its biological activity. Additionally, Spirendolol may possess intrinsic sympathomimetic activity, allowing it to partially stimulate beta receptors while blocking them, which can lead to a more balanced cardiovascular response. Its pharmacokinetic properties include moderate absorption and metabolism, with a potential for interactions with other medications. As with many beta-blockers, common side effects may include fatigue, dizziness, and gastrointestinal disturbances. Overall, Spirendolol represents a valuable option in the management of cardiovascular diseases, although its use should be tailored to individual patient needs and conditions.

Formula: C₂₁H₃₁NO₃

InChI: InChI=1S/C21H31NO3/c1-20(2,3)22-13-15(23)14-25-18-9-7-8-16-17(18)12-21(19(16)24)10-5-4-6-11-21/h7-9,15,22-23H,4-6,10-14H2,1-3H3

InChI key: InChIKey=YLBMSIZZTJEEIO-UHFFFAOYSA-N

SMILES: O=C1C2(CC=3C1=CC=CC3OCC(CNC(C)(C)C)O)CCCCC2

Synonyms:

• Spiro[cyclohexane-1,2′-[2H]inden]-1′(3′H)-one, 4′-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-
• 4′-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]spiro[cyclohexane-1,2′-[2H]inden]-1′(3′H)-one
• Substance 32468
• S 32-468
• Li 32-468

Spirendolol

CAS: 81840-58-6

Spirendolol is a beta-adrenergic receptor agonist that is used in the treatment of cardiac arrhythmias. It acts as an inhibitor of the enzyme phosphodiesterase, which is responsible for breaking down cyclic AMP (cAMP). This increases the levels of cAMP and leads to relaxation of smooth muscles and increased heart rate. Spirendolol also has antiarrhythmic properties by inhibiting potassium channels, which are vital for cardiac function. Spirendolol binds to the benzyl group, a chemical moiety found in many drugs, and the cycloalkenyl group, which is found in fatty acids. Molecular modeling studies have shown that spirendolol binds with high affinity to lipoprotein-associated receptors on cardiomyocytes, leading to ventricular dysfunction and congestive heart failure. Spirendolol also inhibits hydrochloric acid production by binding to a chloride ion channel on parietal cells in

Formula: C₂₁H₃₁NO₃

Purity: Min. 95%

Molecular weight: 345.5 g/mol

Ref: 3D-GDA84058

Spirendolol

CAS: 81840-58-6

Spirendolol is an antagonist of β adrenergic receptor.

Formula: C₂₁H₃₁NO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 345.48

Ref: TM-T16919