CAS 81846-19-7

Treprostinil

Description:

Treprostinil is a synthetic analog of prostacyclin, a naturally occurring compound that plays a crucial role in vasodilation and inhibition of platelet aggregation. It is primarily used in the treatment of pulmonary arterial hypertension (PAH) to improve exercise capacity and delay clinical worsening. Treprostinil is characterized by its ability to relax blood vessels and improve blood flow, which is essential in managing PAH. The substance is typically administered via continuous intravenous infusion, subcutaneous injection, or inhalation, depending on the formulation. Treprostinil has a relatively short half-life, necessitating continuous delivery for sustained therapeutic effects. Its chemical structure includes a bicyclic ring system and multiple functional groups that contribute to its biological activity. The compound is known for its stability under physiological conditions, although it can be sensitive to light and temperature. Common side effects associated with treprostinil treatment include headache, flushing, and gastrointestinal disturbances, which are related to its vasodilatory effects. Overall, treprostinil represents a significant advancement in the management of PAH, offering patients improved quality of life.

Formula: C₂₃H₃₄O₅

InChI: InChI=1S/C23H34O5/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27)/t16-,17-,18+,19-,21+/m0/s1

InChI key: InChIKey=PAJMKGZZBBTTOY-ZFORQUDYSA-N

SMILES: C(C[C@H](CCCCC)O)[C@@H]1[C@@]2([C@@](CC=3C(C2)=CC=CC3OCC(O)=O)(C[C@H]1O)[H])[H]

Synonyms:

• ({(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl}oxy)acetic acid
• Acetic acid, [[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]-
• Acetic acid, 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]-
• 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic acid
• Acetic acid, [[2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-(3-hydroxyoctyl)-1H-benz[f]inden-5-yl]oxy]-, [1R-[1α(S*),2β,3aα,9aα]]-
• 1H-Benz[f]indene, acetic acid deriv.

Treprostinil

CAS: 81846-19-7

Formula: C₂₃H₃₄O₅

Color and Shape: White To Off-White Solid

Molecular weight: 390.52

Ref: 4Z-T-831

Treprostinil

CAS: 81846-19-7

Treprostinil

Purity: ≥98%

Molecular weight: 390.51g/mol

Ref: 54-BUP05898

Treprostinil-13C2-d1

CAS: 81846-19-7

Formula: C₂₁₁₃C₂H₃₃DO₅

Color and Shape: Pale Yellow Solid

Molecular weight: 393.51

Ref: 4Z-T-833

Treprostinil

CAS: 81846-19-7

Treprostinil (Orenitram) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).

Formula: C₂₃H₃₄O₅

Purity: 99.29%

Color and Shape: Solid

Molecular weight: 390.51

Ref: TM-T5150

Treprostinil

CAS: 81846-19-7

Treprostinil is a vasodilator that is used to treat pulmonary hypertension. It is also used to treat congestive heart failure, and has been shown to have potential in the treatment of Parkinson's disease and other neurological disorders. Treprostinil was developed for the treatment of pulmonary arterial hypertension (PAH) by improving blood flow in the lungs. Treprostinil is an analog of prostacyclin, which is a naturally occurring substance produced by the body that causes blood vessels to relax and widen. Treprostinil binds to platelets and causes them to release substances that cause blood vessels to widen, leading to improved blood flow in the lungs. This drug can be given by mouth or intravenously and has few side effects at therapeutic doses, although it may cause liver problems or high blood pressure when taken orally.

Formula: C₂₃H₃₄O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 390.51 g/mol

Ref: 3D-FT28376

Treprostinil

Controlled Product

CAS: 81846-19-7

Applications Synthetic analog of Prostacyclin (P839060). Antihypertensive. Treprostinil, marketed under the trade name Remodulin is a medication used to treat pulmonary arterial hypertension (PAH).
References Laliberte, K., et al.: J. Cardiovasc. Pharmacol., 44, 209 (2004),

Formula: C₂₃H₃₄O₅

Color and Shape: Neat

Molecular weight: 390.51

Ref: TR-T719500

Treprostinil-d4

Controlled Product

CAS: 81846-19-7

Applications Isotope labelled analogue of Treprostinil (T719502), a synthetic analog of Prostacyclin (P839060). Antihypertensive. Treprostinil, marketed under the trade name Remodulin is a medication used to treat pulmonary arterial hypertension (PAH).
References Laliberte, K., et al.: J. Cardiovasc. Pharmacol., 44, 209 (2004),

Formula: C₂₃D₄H₃₀O₅

Color and Shape: Neat

Molecular weight: 394.538

Ref: TR-T719502