CAS 81872-10-8

Zofenopril

Description:

Zofenopril is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. It is characterized by its ability to inhibit the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure. The chemical structure of zofenopril includes a thiol group, which is essential for its activity, and it is often administered as its prodrug form, zofenoprilat, which is the active metabolite. Zofenopril exhibits a relatively long half-life, allowing for once-daily dosing in clinical practice. It is generally well-tolerated, though potential side effects may include cough, hyperkalemia, and renal impairment, similar to other ACE inhibitors. Additionally, zofenopril has been noted for its cardioprotective effects beyond blood pressure reduction, contributing to improved outcomes in patients with heart failure. As with any medication, it is important for patients to discuss their medical history and any potential drug interactions with their healthcare provider before starting treatment.

Formula: C₂₂H₂₃NO₄S₂

InChI: InChI=1S/C22H23NO4S2/c1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17/h2-11,15,18-19H,12-14H2,1H3,(H,25,26)/t15-,18+,19+/m1/s1

InChI key: InChIKey=IAIDUHCBNLFXEF-MNEFBYGVSA-N

SMILES: C([C@@H](CSC(=O)C1=CC=CC=C1)C)(=O)N2[C@H](C(O)=O)C[C@H](SC3=CC=CC=C3)C2

Synonyms:

• (4S)-1-[(2S)-3-(Benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-<span class="text-smallcaps">L</span>-proline
• (4S)-1-[(2S)-3-(benzoylsulfanyl)-2-methylpropanoyl]-4-(phenylsulfanyl)-L-proline
• (4S)-N-[3-(Benzoylsulfanyl)-2(S)-Methylpropionyl]-4-(Phenylsulfanyl)-L-Proline
• <span class="text-smallcaps">L</span>-Proline, 1-[(2S)-3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-, (4S)-
• <span class="text-smallcaps">L</span>-Proline, 1-[3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-, [1(R*),2α,4α]-
• Zofenopril
• L-Proline, 1-[(2S)-3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-, (4S)-
• L-Proline, 1-[3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-, [1(R*),2α,4α]-
• (4S)-1-[(2S)-3-(Benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-L-proline

Zofenopril-d5 (Benzoic-d5)

CAS: 81872-10-8

Formula: C₂₂H₁₈D₅NO₄S₂

Color and Shape: White To Off-White Solid

Molecular weight: 434.58

Ref: 4Z-Z-092

Zofenopril-d5 (Thiophenyl-d5)

CAS: 81872-10-8

Formula: C₂₂H₁₈D₅NO₄S₂

Molecular weight: 434.59

Ref: 4Z-Z-097

Zofenopril

CAS: 81872-10-8

Zofenopril is an angiotensin-converting enzyme (ACE) inhibitor (IC50: 81 μM).

Formula: C₂₂H₂₃NO₄S₂

Color and Shape: Solid

Molecular weight: 429.55

Ref: TM-T62377

Zofenopril calcium

CAS: 81872-10-8

Angiotensin-converting enzyme inhibitor; antioxidant

Formula: C₄₄H₄₆N₂O₈S₄•Ca

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 899.17 g/mol

Ref: 3D-FZ28770