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CAS 81907-81-5

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7-Hydroxypropranolol

Description:
7-Hydroxypropranolol is a chemical compound that serves as a metabolite of propranolol, a non-selective beta-adrenergic antagonist commonly used to treat various cardiovascular conditions, anxiety, and migraine prophylaxis. This compound is characterized by its hydroxyl group at the 7-position of the naphthalene ring, which contributes to its pharmacological properties. It is typically a white to off-white solid and is soluble in water and organic solvents, reflecting its polar nature due to the presence of the hydroxyl group. The molecular structure of 7-Hydroxypropranolol allows it to interact with beta-adrenergic receptors, albeit with different affinities compared to its parent compound. Its role in the body includes influencing cardiovascular function and potentially modulating the effects of propranolol. Additionally, 7-Hydroxypropranolol is of interest in pharmacokinetic studies, as it can provide insights into the metabolism and efficacy of propranolol therapy. As with many metabolites, understanding its characteristics is crucial for evaluating drug interactions and therapeutic outcomes.
Formula:C16H21NO3
InChI:InChI=1S/C16H21NO3/c1-11(2)17-9-14(19)10-20-16-5-3-4-12-6-7-13(18)8-15(12)16/h3-8,11,14,17-19H,9-10H2,1-2H3
InChI key:InChIKey=ZAVISZICVBECEV-UHFFFAOYSA-N
SMILES:O(CC(CNC(C)C)O)C=1C2=C(C=CC1)C=CC(O)=C2
Synonyms:
  • 2-Naphthalenol, 8-[2-Hydroxy-3-[(1-Methylethyl)Amino]Propoxy]-
  • 7-Hydroxypropranolol
  • 8-[2-Hydroxy-3-(Propan-2-Ylamino)Propoxy]Naphthalen-2-Ol
  • 8-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-2-naphthalenol
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  • rac 7-Hydroxy Propranolol
    TRC
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    rac 7-Hydroxy Propranolol

    Controlled Product
    CAS:
    <p>Applications A metabolite of Propranolol.<br>References Otton, S., et al.: Br. J. Clin. Pharmacol., 30, 751 (1990), Fujita, S., et al.: J. Pharmacol. Exp. Ther., 264, 226 (1993), Bichara, N., et al.: Drug Metab. Dispos., 24, 112 (1996), Tasaki, T., et al.: J. Biochem., 123, 162 (1998),<br></p>
    Formula:C16H21NO3
    Color and Shape:Neat
    Molecular weight:275.34

    Ref: TR-H952555

    1mg
    302.00€
    5mg
    1,232.00€