CAS 81938-43-4

Zofenopril calcium

Description:

Zofenopril calcium is a pharmaceutical compound primarily used as an antihypertensive agent. It belongs to the class of angiotensin-converting enzyme (ACE) inhibitors, which function by inhibiting the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure. The compound is characterized by its calcium salt form, which enhances its solubility and bioavailability. Zofenopril exhibits a unique structure that includes a thiol group, contributing to its pharmacological activity. It is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing. In addition to its antihypertensive effects, zofenopril may also provide renal protective benefits, particularly in patients with diabetes. Common side effects may include dizziness, cough, and elevated potassium levels. As with other ACE inhibitors, caution is advised in patients with a history of angioedema or renal impairment. Overall, zofenopril calcium is an effective medication for managing hypertension and improving cardiovascular health.

Formula: C₄₄H₄₄CaN₂O₈S₄

InChI: InChI=1/2C22H23NO4S2.Ca/c2*1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17;/h2*2-11,15,18-19H,12-14H2,1H3,(H,25,26);/q;;+2/p-2/t2*15-,18+,19+;/m11./s1

InChI key: InChIKey=ITYYOFPEROWRNL-BQBHMPFISA-N

SMILES: C([C@@H](CSC(=O)C1=CC=CC=C1)C)(=O)N2[C@H](C(O)=O)C[C@H](SC3=CC=CC=C3)C2.[Ca]

Synonyms:

• (4S)-N-[3-(Benzoylsulfanyl)-2(S)-methylpropionyl]-4-(phenylsulfanyl)-L-proline calcium salt
• <span class="text-smallcaps">L</span>-Proline, 1-[(2S)-3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-, calcium salt (2:1), (4S)-
• <span class="text-smallcaps">L</span>-Proline, 1-[3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-, calcium salt, [1(R*),2α,4α]-
• Sq 26991
• Zofenil
• Zoprace
• calcium bis[(2S,4S)-1-{(2S)-2-methyl-3-[(phenylcarbonyl)sulfanyl]propanoyl}-4-(phenylsulfanyl)pyrrolidine-2-carboxylate]
• L-Proline, 1-[3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-, calcium salt, [1(R*),2α,4α]-
• Zofenopril calcium
• L-Proline, 1-[(2S)-3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-, calcium salt (2:1), (4S)-
• ZOFENOPRILCALCIUMSALT(FORRESEARCHONLY)
• Zofenopril Calciun Salt
• Bifril
• ZOFENOPRIL CALCIUM SALT
• [1(S),4(S)]-1-(3-Mercapto-2-methyl-1-oxopropyl)-4-phenyl-thio-L-proline-S-benzoyl Ester Calcium Salt
• [(4S)-(2S)-3-(benzoylthio)-2-methylpro-pionyl-4-(phenylthio)-L-prolinelcalcium

Zofenopril calcium

CAS: 81938-43-4

Zofenopril calcium

Purity: ≥98%

Molecular weight: 897.17g/mol

Ref: 54-BUP10399

Zofenopril (Calcium)

CAS: 81938-43-4

Zofenopril (Calcium)

Purity: 98%

Molecular weight: 897.17g/mol

Ref: 54-IN11673

Zofenopril Calcium Salt

CAS: 81938-43-4

Formula: C₂₂H₂₂NO₄S₂·5Ca

Color and Shape: White To Off-White Solid

Molecular weight: 428.55 0.5*40.08

Ref: 4Z-Z-091

Zofenopril calcium salt

CAS: 81938-43-4

Formula: C₂₂H₂₂NO₄S₂·5Ca

Purity: ≥ 97.0%

Color and Shape: White to off-white powder

Molecular weight: 448.58

Ref: 7W-GP9021

Zofenopril Calcium

CAS: 81938-43-4

Formula: C₄₄H₄₄CaN₂O₈S₄

Purity: >97.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 897.16

Ref: 3B-Z0041

Zofenopril calcium

CAS: 81938-43-4

Zofenopril calcium (SQ26991) is an antioxidant that acts as an angiotensin-converting enzyme inhibitor.

Formula: C₄₄H₄₄CaN₂O₈S₄

Purity: 98.37%

Color and Shape: White Or Whitish Crystalline Powder

Molecular weight: 897.17

Ref: TM-T5030

Zofenopril Calcium Salt

CAS: 81938-43-4

Applications Angiotensin-converting enzyme ACE inhibitor. A prodrug that is de-esterified to the active inhibitor, the sulfhydryl group containing metabolite, Zofenoprilat.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gorren, A., et al.: Biochem. J., 331, 801 (1998), Subissi, A., et al.: Cardivascular Drug Reviews, 17, 2 (1999), Marchand, C., et al.: Mol. Pharmacol., 64, 600 (2003), Maurin, C., et al.: J. Med. Chem., 47, 5583 (2004),

Formula: C₂₂H₂₂NO₄S₂·Ca

Color and Shape: Neat

Molecular weight: 897.17

Ref: TR-Z587000

ZOFENOPRIL CALCIUM

CAS: 81938-43-4

Purity: 98%

Molecular weight: 897.1599731

Ref: 10-F802063