CAS 81957-25-7

Dazopride fumarate

Description:

Dazopride fumarate is a pharmaceutical compound primarily used for its gastroprokinetic properties, which aid in enhancing gastrointestinal motility. It is a derivative of the benzamide class and functions as a selective 5-HT4 receptor agonist, promoting the release of acetylcholine in the gastrointestinal tract, thereby facilitating peristalsis. The fumarate salt form enhances its solubility and stability, making it suitable for oral administration. Dazopride is often investigated for its potential in treating conditions such as functional dyspepsia and gastroesophageal reflux disease (GERD). Its pharmacological profile includes a favorable safety margin, although side effects may include gastrointestinal disturbances. The compound's mechanism of action is primarily linked to its interaction with serotonin receptors, which play a crucial role in regulating gut motility. As with any pharmaceutical agent, its use should be guided by clinical evidence and regulatory approvals, ensuring that it is administered in appropriate contexts to maximize therapeutic benefits while minimizing risks.

Formula: C₁₅H₂₃ClN₄O₂·C₄H₄O₄

InChI: InChI=1S/C15H23ClN4O2.C4H4O4/c1-4-19-8-10(9-20(19)5-2)18-15(21)11-6-12(16)13(17)7-14(11)22-3;5-3(6)1-2-4(7)8/h6-7,10H,4-5,8-9,17H2,1-3H3,(H,18,21);1-2H,(H,5,6)(H,7,8)/b;2-1+

InChI key: InChIKey=IGGKTAIAQUIFKQ-WLHGVMLRSA-N

SMILES: C(NC1CN(CC)N(CC)C1)(=O)C2=C(OC)C=C(N)C(Cl)=C2.C(=C/C(O)=O)\C(O)=O

Synonyms:

• AHR 5531C
• Dazopride fumarate
• Benzamide, 4-amino-5-chloro-N-(1,2-diethyl-4-pyrazolidinyl)-2-methoxy-, (E)-2-butenedioate (1:1)
• Benzamide, 4-amino-5-chloro-N-(1,2-diethyl-4-pyrazolidinyl)-2-methoxy-, (2E)-2-butenedioate (1:1)

Dazopride fumarate

CAS: 81957-25-7

Dazopride fumarate is a peristaltic used to enhance gastric emptying and block emesis.

Formula: C₁₉H₂₇ClN₄O₆

Color and Shape: Solid

Molecular weight: 442.89

Ref: TM-T31214