CAS 82-08-6

Rottlerin

Description:

Rottlerin, with the CAS number 82-08-6, is a naturally occurring compound derived from the plant Mallotus philippinensis. It is classified as a flavonoid and is known for its distinctive yellow color. Rottlerin exhibits a range of biological activities, including anti-inflammatory, antioxidant, and potential anticancer properties. Its mechanism of action is primarily attributed to its ability to inhibit protein kinase C (PKC), which plays a crucial role in various cellular processes, including cell growth and differentiation. Additionally, Rottlerin has been studied for its effects on various signaling pathways, making it a subject of interest in pharmacological research. The compound is soluble in organic solvents but has limited solubility in water, which can affect its bioavailability and therapeutic applications. Due to its diverse biological effects, Rottlerin is being explored for potential use in treating various diseases, although further research is necessary to fully understand its efficacy and safety in clinical settings.

Formula: C₃₀H₂₈O₈

InChI: InChI=1/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+

InChI key: InChIKey=DEZFNHCVIZBHBI-ZHACJKMWSA-N

SMILES: C(/C=C/C1=CC=CC=C1)(=O)C2=C3C(=C(O)C(CC4=C(O)C(C(C)=O)=C(O)C(C)=C4O)=C2O)C=CC(C)(C)O3

Synonyms:

• (2E)-1-[6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-3-phenylprop-2-en-1-one
• (2E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one
• 2-Propen-1-one, 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-, (2E)-
• 2-Propen-1-one, 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-, (E)-
• Acetophenone, 3'-((8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl)-2',4',6'-trihydroxy-5'-methyl-
• Acetophenone, 3′-[(8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2′,4′,6′-trihydroxy-5′-methyl-
• Brn 0070757
• Kamalin
• Mallotoxin
• Nsc 56346
• Nsc 94525
• PKC-δ/PKC-θ inhibitor
• Rottlerin
• (E)-1-(6-((3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl)-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one
• 5-18-05-00695 (Beilstein Handbook Reference)
• 3'-[(8-CINNAMOYL-5,7-DIHYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-6-YL)METHYL]-2',4',6'-TRIHYDROXY-5'-METHYLACETOPHENONE
• 4’,6’-trihydroxy-5’-methyl-methyl)-2
• acetophenone,3’-((8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-6-yl)
• 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one

Rottlerin

CAS: 82-08-6

Formula: C₃₀H₂₈O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 516.5385

Ref: IN-DA00G2JN

Rottlerin

CAS: 82-08-6

Rottlerin

Purity: ≥95%

Molecular weight: 516.54g/mol

Ref: 54-BUP06758

Rottlerin

CAS: 82-08-6

Formula: C₃₀H₂₈O₈

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: Light yellow to Brown powder to crystal

Molecular weight: 516.55

Ref: 3B-R0266

Rottlerin

CAS: 82-08-6

Formula: C₃₀H₂₈O₈

Molecular weight: 516.54

Ref: 7W-GL6758

Rottlerin

CAS: 82-08-6

Formula: C₃₀H₂₈O₈

Molecular weight: 516.55

Ref: 4Z-R-127001

Rottlerin

CAS: 82-08-6

Rottlerin (NSC-56346), a Mallotus Philippinensis extract, inhibits PKC (3-100 μM IC50); triggers apoptosis by activating caspase 3.

Formula: C₃₀H₂₈O₈

Purity: 97.41% - 99.44%

Color and Shape: Orange To Brown Powder

Molecular weight: 516.54

Ref: TM-T16791

Rottlerin

Controlled Product

CAS: 82-08-6

Applications Rottlerin is a human ether-a-go-go-related gene (hERG) potassium channel activator.
References Zeng, H., et al.: J. Pharmacol. Exp. Ther., 319, 957 (2006)

Formula: C₃₀H₂₈O₈

Color and Shape: Neat

Molecular weight: 516.54

Ref: TR-R700740

Rottlerin

CAS: 82-08-6

Rottlerin is a polyphenolic compound, which is a natural product derived from the plant species Mallotus philippensis. It is primarily isolated from the fruits or glands of this plant. Rottlerin operates as a selective inhibitor, notably targeting specific protein kinases such as PKC-delta (Protein Kinase C delta). It also affects various other cellular processes and pathways, offering a diverse range of biological effects.

Formula: C₃₀H₂₈O₈

Purity: Min. 95 Area-%

Color and Shape: Orange Powder

Molecular weight: 516.54 g/mol

Ref: 3D-FR29637

Rottlerin

CAS: 82-08-6

M02456 - Rottlerin

Formula: C₃₀H₂₈O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 516.546

Ref: 10-M02456