CAS 82-95-1

buclizine

Description:

Buclizine is an antihistamine belonging to the piperazine class, primarily used for its antiemetic properties to prevent nausea and vomiting associated with motion sickness. It is characterized by its ability to cross the blood-brain barrier, which contributes to its sedative effects. Buclizine exhibits a moderate affinity for H1 histamine receptors, leading to its effectiveness in alleviating allergic symptoms. The compound is typically administered orally and is available in various formulations, including tablets and syrup. Its chemical structure includes a piperazine ring, which is essential for its pharmacological activity. Buclizine is generally well-tolerated, but like other antihistamines, it may cause side effects such as drowsiness, dry mouth, and dizziness. It is important to use buclizine under medical supervision, especially in individuals with pre-existing health conditions or those taking other medications, to avoid potential interactions. Overall, buclizine serves as a valuable therapeutic agent in managing motion sickness and related symptoms.

Formula: C₂₈H₃₃ClN₂

InChI: InChI=1S/C28H33ClN2/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24/h4-16,27H,17-21H2,1-3H3

InChI key: InChIKey=MOYGZHXDRJNJEP-UHFFFAOYSA-N

SMILES: C(N1CCN(CC2=CC=C(C(C)(C)C)C=C2)CC1)(C3=CC=C(Cl)C=C3)C4=CC=CC=C4

Synonyms:

• 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine
• 1-(4-Tert-Butylbenzyl)-4-(4-Chlorobenzhydryl)Piperazine
• 1-(p-Chloro-α-phenylbenzyl)-4-(p-tert-butylbenzyl)piperazine
• 1-(p-Chlorobenzhydryl)-4-(p-tert-butylbenzyl)-diethylenediamine
• 1-(p-Chlorobenzhydryl)-4-(p-tert-butylbenzyl)-piperazine
• 1-(p-tert-Butylbenzyl)-4-(p-chloro-α-phenylbenzyl)piperazine
• 1-[(4-Chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]piperazine
• Ah 2526
• Aphilan R base
• Buclifen
• Buclizin
• Buclizina
• Histabuticine
• Histabutizine
• Histabutyzine
• Hitabutyzyne
• Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)-
• Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-
• Posdel
• Postafen

Buclizine

CAS: 82-95-1

Formula: C₂₈H₃₃ClN₂

Purity: 97%

Molecular weight: 433.0280

Ref: IN-DA00G4DC

1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine

CAS: 82-95-1

1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine

Purity: 97%

Molecular weight: 433.04g/mol

Ref: 54-OR1069313

Buclizine

CAS: 82-95-1

Buclizine is an orally active antihistamine, antiallergic compound. buclizine is also a strong teratogen in rats and exhibits antitumour effects.

Formula: C₂₈H₃₃ClN₂

Color and Shape: Solid

Molecular weight: 433.03

Ref: TM-T62421