CAS 82005-12-7

Hymenialdisine

Description:

Hymenialdisine is a naturally occurring alkaloid primarily isolated from marine sponges, particularly those belonging to the genus Hymeniacidon. It is characterized by its complex molecular structure, which includes a bicyclic framework. This compound exhibits notable biological activity, particularly as an inhibitor of protein kinases, which are crucial for various cellular processes. Hymenialdisine has garnered interest in medicinal chemistry due to its potential therapeutic applications, including anti-cancer properties. Its mechanism of action involves the modulation of signaling pathways, making it a subject of research in drug development. Additionally, hymenialdisine is known for its low toxicity in certain biological contexts, although further studies are necessary to fully understand its pharmacokinetics and safety profile. The compound is typically studied in the context of marine natural products and their potential applications in pharmaceuticals, highlighting the importance of marine biodiversity in drug discovery.

Formula: C₁₁H₁₀BrN₅O₂

InChI: InChI=1S/C11H10BrN5O2/c12-6-3-5-4(7-10(19)17-11(13)16-7)1-2-14-9(18)8(5)15-6/h3,15H,1-2H2,(H,14,18)(H3,13,16,17,19)/b7-4-

InChI key: InChIKey=ATBAETXFFCOZOY-DAXSKMNVSA-N

SMILES: O=C1C2=C(/C(/CCN1)=C\3/C(=O)N=C(N)N3)C=C(Br)N2

Synonyms:

• (4E)-4-(2-amino-5-oxo-1,5-dihydro-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one
• (4Z)-4-(2-Amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one
• (Z)-Hymenialdisine
• 10Z-Hymenialdisine
• Hymenialdesine
• Hymenialdisine
• Pyrrolo[2,3-c]azepin-8(1H)-one, 4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-, (4Z)-
• Pyrrolo[2,3-c]azepin-8(1H)-one, 4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-, (Z)-
• pyrrolo[2,3-c]azepin-8(1H)-one, 4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-, (4E)-

10Z-Hymenialdisine

CAS: 82005-12-7

Formula: C₁₁H₁₀BrN₅O₂

Molecular weight: 324.1

Ref: 7W-GL2243

Hymenialdisine Methanoate

Controlled Product

CAS: 82005-12-7, 84094-94-0

Applications A potent inhibitor of a variety of kinases including MEK-1, GSK-3Β, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations. A marine sponge alkaloid, a natural product.
References Cheetham, G., et al.: J. Biol. Chem., 277, 42419 (2002), Bain, J., et al.: Biochem. J., 371, 199 (2003), Sharma, V., et al.: Bioorg. Med. Chem. Lett., 14, 4319 (2004), Anamika, et al.: Proteins, 58, 180 (2005), Birault, V., et al.: Curr. Med. Chem., 13, 1735 (2006),

Formula: C₁₁H₁₀BrN₅O₂·x(CH₄O)

Color and Shape: Neat

Molecular weight: 324.13 + x(32.04)

Ref: TR-H998000

10Z-Hymenialdisine

CAS: 82005-12-7

Pan kinase inhibitor

Formula: C₁₁H₁₀BrN₅O₂

Purity: 98%

Color and Shape: Light Yellow Solid

Molecular weight: 324.13

Ref: TM-T22470